@article{cdea6621bf0645a5bb8a781aeaddcb99,
title = "The investigation of acute optic neuritis: A review and proposed protocol",
abstract = "Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of MS-associated optic neuritis from other autoimmune and inflammatory optic neuropathies is vital for treatment choice and further patient management, but is not always straightforward. Over the past decade, a number of new imaging, laboratory and electrophysiological techniques have entered the clinical arena. To date, however, no consensus guidelines have been devised to specify how and when these techniques can be most rationally applied for the diagnostic work-up of patients with acute optic neuritis. In this article, we review the literature and attempt to formulate a consensus for the investigation of patients with acute optic neuritis, both in standard care and in research with relevance to clinical treatment trials.",
author = "Axel Petzold and Wattjes, {Mike P.} and Fiona Costello and Jose Flores-Rivera and Fraser, {Clare L.} and Kazuo Fujihara and Jacqueline Leavitt and Romain Marignier and Friedemann Paul and Sven Schippling and Christian Sindic and Pablo Villoslada and Brian Weinshenker and Plant, {Gordon T.}",
note = "Funding Information: The MS Center VUMC is partially funded by a programme grant from the Dutch MS Research Foundation. K.F. is a recipient of Grants-in-Aid for Scientific Research from the Ministry of Education, Science and Technology and the Ministry of Health, Labour and Welfare of Japan. F.P. is supported by the German Research Council (DFG Exc 257) and the German Ministry for Education and Research Competence Network Multiple Sclerosis. S.S. is supported by the Clinical Research Priority Program of the University of Z{\"u}rich and the Betty and David Koetser Foundation for Brain Research. G.T.P. is supported by the University College London Comprehensive Biomedical Research Centre and the Moorfields Biomedical Research Centre.",
year = "2014",
month = aug,
doi = "10.1038/nrneurol.2014.108",
language = "English (US)",
volume = "10",
pages = "447--458",
journal = "Nature Reviews Neurology",
issn = "1759-4758",
publisher = "Nature Publishing Group",
number = "8",
}