The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

Wai Po Chong; W. K.Eddie Ip; Gloria Hoi Wan Tso; Man Wai Ng; Wilfred Hing Sang Wong; Helen Ka Wai Law; Raymond W.H. Yung; Eudora Y. Chow; K. L. Au; Eric Y.T. Chan; Wilina Lim; J. S.Malik Peiris; Yu Lung Lau

doi:10.1186/1471-2334-6-82

The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

Wai Po Chong, W. K.Eddie Ip, Gloria Hoi Wan Tso, Man Wai Ng, Wilfred Hing Sang Wong, Helen Ka Wai Law, Raymond W.H. Yung, Eudora Y. Chow, K. L. Au, Eric Y.T. Chan, Wilina Lim, J. S.Malik Peiris, Yu Lung Lau

Immunology

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Abstract

Background: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility.

Original language	English (US)
Article number	82
Journal	BMC Infectious Diseases
Volume	6
DOIs	https://doi.org/10.1186/1471-2334-6-82
State	Published - May 4 2006

ASJC Scopus subject areas

Infectious Diseases

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@article{b1498cd016b44215a5ae32dc37dd8aee,

title = "The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome",

abstract = "Background: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility.",

author = "Chong, {Wai Po} and Ip, {W. K.Eddie} and Tso, {Gloria Hoi Wan} and Ng, {Man Wai} and Wong, {Wilfred Hing Sang} and Law, {Helen Ka Wai} and Yung, {Raymond W.H.} and Chow, {Eudora Y.} and Au, {K. L.} and Chan, {Eric Y.T.} and Wilina Lim and Peiris, {J. S.Malik} and Lau, {Yu Lung}",

year = "2006",

month = may,

day = "4",

doi = "10.1186/1471-2334-6-82",

language = "English (US)",

volume = "6",

journal = "BMC Infectious Diseases",

issn = "1471-2334",

publisher = "BioMed Central",

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TY - JOUR

T1 - The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

AU - Chong, Wai Po

AU - Ip, W. K.Eddie

AU - Tso, Gloria Hoi Wan

AU - Ng, Man Wai

AU - Wong, Wilfred Hing Sang

AU - Law, Helen Ka Wai

AU - Yung, Raymond W.H.

AU - Chow, Eudora Y.

AU - Au, K. L.

AU - Chan, Eric Y.T.

AU - Lim, Wilina

AU - Peiris, J. S.Malik

AU - Lau, Yu Lung

PY - 2006/5/4

Y1 - 2006/5/4

N2 - Background: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility.

AB - Background: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility.

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DO - 10.1186/1471-2334-6-82

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JO - BMC Infectious Diseases

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ER -

The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

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