The Insulin-Like Growth Factor System in Cancer

Saravut (John) Weroha, Paul Haluska

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Insulin-like growth factor (IGF) plays an important role in tissue growth and development. Several studies have demonstrated the association between circulating levels of IGF-1 and -2 and cancer risk, and the IGF system has been implicated in the oncogenesis of essentially all solid and hematologic malignancies. The optimal strategy for targeting IGF signaling in patients with cancer is not clear. The modest benefits reported thus far underscore the need for a better understanding of IGF signaling, which would enable clinicians to identify the subset of patients with the greatest likelihood of attaining benefit from this targeted approach.

Original languageEnglish (US)
Pages (from-to)335-350
Number of pages16
JournalEndocrinology and Metabolism Clinics of North America
Volume41
Issue number2
DOIs
StatePublished - Jun 2012

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Somatomedins
Neoplasms
Hematologic Neoplasms
Growth and Development
Carcinogenesis

Keywords

  • Cancer risk stratification
  • Growth hormone
  • Insulin-like growth factor
  • Signal transduction

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

The Insulin-Like Growth Factor System in Cancer. / Weroha, Saravut (John); Haluska, Paul.

In: Endocrinology and Metabolism Clinics of North America, Vol. 41, No. 2, 06.2012, p. 335-350.

Research output: Contribution to journalArticle

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