The Insulin-Like Growth Factor System in Cancer

S. John Weroha, Paul Haluska

Research output: Contribution to journalReview article

102 Scopus citations


Insulin-like growth factor (IGF) plays an important role in tissue growth and development. Several studies have demonstrated the association between circulating levels of IGF-1 and -2 and cancer risk, and the IGF system has been implicated in the oncogenesis of essentially all solid and hematologic malignancies. The optimal strategy for targeting IGF signaling in patients with cancer is not clear. The modest benefits reported thus far underscore the need for a better understanding of IGF signaling, which would enable clinicians to identify the subset of patients with the greatest likelihood of attaining benefit from this targeted approach.

Original languageEnglish (US)
Pages (from-to)335-350
Number of pages16
JournalEndocrinology and Metabolism Clinics of North America
Issue number2
StatePublished - Jun 1 2012



  • Cancer risk stratification
  • Growth hormone
  • Insulin-like growth factor
  • Signal transduction

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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