The Incidence and Severity of Oral Mucositis among Allogeneic Hematopoietic Stem Cell Transplantation Patients: A Systematic Review

Hafsa M. Chaudhry, Alison Bruce, Robert C. Wolf, Mark R Litzow, William Hogan, Mrinal M Patnaik, Walter K Kremers, Gordon L. Phillips, Shahrukh K. Hashmi

Research output: Contribution to journalArticle

26 Scopus citations


Oral mucositis (OM) is a debilitating early adverse effect of allogeneic hematopoietic stem cell transplantation (HSCT). The intensity of the conditioning regimen correlates with the incidence and severity of OM, but no studies have analyzed this relationship among various conditioning regimens. We performed a systematic review on the incidence and outcomes of OM in allogeneic HSCT patients and analyzed this association. A comprehensive search of several databases (Ovid Medline In-Process & Other Non-Indexed Citations, Ovid MEDLINE, Ovid EMBASE, Cochrane CRCT, Cochrane DSR, Scopus) from 1990 to 2014 for studies of OM in allogeneic HSCT patients was conducted. Professional societies' meeting abstracts were also searched. Grade of OM was analyzed based on the World Health Organization (WHO) or National Cancer Institutes (NCI) Common Terminology Criteria for Adverse Events scales. Severe mucositis was defined as either grades 2 to 4 or grades 3 and 4, depending on the studies' definition of severity. Cohorts were analyzed based on regimen intensity; ie, reduced-intensity conditioning (RIC) (including nonmyeloablative) and myeloablative (MA). Random effect (RE) and standard logistic models weighted by the number of patients in each cohort were used for comparisons. A total of 624 studies were generated from the search. Of the 395 patients in 8 eligible MA regimen studies, 73.2% experienced any OM, whereas in 245 patients in the 6 eligible RIC regimen studies, 86.5% experienced any OM (chi-square P

Original languageEnglish (US)
Pages (from-to)605-616
Number of pages12
JournalBiology of Blood and Marrow Transplantation
Issue number4
StatePublished - Apr 1 2016



  • Allogeneic hematopoietic stem cell transplantation
  • Mucosal barrier injury
  • Oral mucositis
  • Transplantation-related toxicity

ASJC Scopus subject areas

  • Transplantation
  • Hematology

Cite this