The impact of parturition and severe preeclampsia on gestational plasma endothelin (ET-1) concentrations

K. G. Perry, R. W. Martin, P. G. Blake, John C Jr. Burnett, J. N. Martin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To determine the effects severe preeclampsia, labor, and parturition have on endothelin (ET-1) concentrations. Methods: Plasma immunoreactive ET-1 concentrations were studied prospectively in 36 gravidas, 13 with severe preeclampsia and 23 normotensive (9 laboring, 14 nonlaboring) controls matched for gestational age. Blood samples were collected from all severe preeclamptic and laboring normotensive control patients following hospital admission, prior to the administration of magnesium sulfate or oxytocin, and 24 h postpartum. A single sample was collected from nonlaboring outpatient control gravidas. ET-1 concentrations were determined by a sensitive radioimmunoassay (Peninsula) and compared between groups by Student's t test, one-way analysis of variance, and linear regression analysis. Results: Plasma ET-1 concentration in severely preeclamptic women was 7.19 ± 0.97 pg/ml compared with 5.63 ± 1.3 pg/ml in the control group (P < 0.05) . ET-1 levels did not decrease significantly 24 h postpartum in either the group with severe preeclampsia (7.19 ± 0.79 vs 7.02 ± 1.34 pg/ml; P > 0.05) or in the laboring normotensive controls (6.12 ± 0.67 vs 6.00 ± 1.04 pg/ml; P > 0.05). ET-1 concentrations were not significantly elevated in laboring vs nonlaboring normotensives (6.12 ± 0.67 vs 5.03 ± 1.25 pg/ml; P > 0.05). Conclusions: ET-1 concentrations were significantly increased in patients with severe preeclampsia compared with normotensive gravidas, and plasma concentrations remained unchanged 24 h postdelivery.

Original languageEnglish (US)
Pages (from-to)129-132
Number of pages4
JournalJournal of Maternal-Fetal Investigation
Volume4
Issue number3
StatePublished - 1994
Externally publishedYes

Fingerprint

Endothelin-1
Pre-Eclampsia
Parturition
Magnesium Sulfate
Oxytocin
Postpartum Period
Gestational Age
Radioimmunoassay
Linear Models
Analysis of Variance
Outpatients
Regression Analysis
Students
Control Groups

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

The impact of parturition and severe preeclampsia on gestational plasma endothelin (ET-1) concentrations. / Perry, K. G.; Martin, R. W.; Blake, P. G.; Burnett, John C Jr.; Martin, J. N.

In: Journal of Maternal-Fetal Investigation, Vol. 4, No. 3, 1994, p. 129-132.

Research output: Contribution to journalArticle

@article{b46718ff57a14024baef8b0a3b4396d0,
title = "The impact of parturition and severe preeclampsia on gestational plasma endothelin (ET-1) concentrations",
abstract = "Objective: To determine the effects severe preeclampsia, labor, and parturition have on endothelin (ET-1) concentrations. Methods: Plasma immunoreactive ET-1 concentrations were studied prospectively in 36 gravidas, 13 with severe preeclampsia and 23 normotensive (9 laboring, 14 nonlaboring) controls matched for gestational age. Blood samples were collected from all severe preeclamptic and laboring normotensive control patients following hospital admission, prior to the administration of magnesium sulfate or oxytocin, and 24 h postpartum. A single sample was collected from nonlaboring outpatient control gravidas. ET-1 concentrations were determined by a sensitive radioimmunoassay (Peninsula) and compared between groups by Student's t test, one-way analysis of variance, and linear regression analysis. Results: Plasma ET-1 concentration in severely preeclamptic women was 7.19 ± 0.97 pg/ml compared with 5.63 ± 1.3 pg/ml in the control group (P < 0.05) . ET-1 levels did not decrease significantly 24 h postpartum in either the group with severe preeclampsia (7.19 ± 0.79 vs 7.02 ± 1.34 pg/ml; P > 0.05) or in the laboring normotensive controls (6.12 ± 0.67 vs 6.00 ± 1.04 pg/ml; P > 0.05). ET-1 concentrations were not significantly elevated in laboring vs nonlaboring normotensives (6.12 ± 0.67 vs 5.03 ± 1.25 pg/ml; P > 0.05). Conclusions: ET-1 concentrations were significantly increased in patients with severe preeclampsia compared with normotensive gravidas, and plasma concentrations remained unchanged 24 h postdelivery.",
author = "Perry, {K. G.} and Martin, {R. W.} and Blake, {P. G.} and Burnett, {John C Jr.} and Martin, {J. N.}",
year = "1994",
language = "English (US)",
volume = "4",
pages = "129--132",
journal = "Journal of Maternal-Fetal Investigation",
issn = "0939-6322",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - The impact of parturition and severe preeclampsia on gestational plasma endothelin (ET-1) concentrations

AU - Perry, K. G.

AU - Martin, R. W.

AU - Blake, P. G.

AU - Burnett, John C Jr.

AU - Martin, J. N.

PY - 1994

Y1 - 1994

N2 - Objective: To determine the effects severe preeclampsia, labor, and parturition have on endothelin (ET-1) concentrations. Methods: Plasma immunoreactive ET-1 concentrations were studied prospectively in 36 gravidas, 13 with severe preeclampsia and 23 normotensive (9 laboring, 14 nonlaboring) controls matched for gestational age. Blood samples were collected from all severe preeclamptic and laboring normotensive control patients following hospital admission, prior to the administration of magnesium sulfate or oxytocin, and 24 h postpartum. A single sample was collected from nonlaboring outpatient control gravidas. ET-1 concentrations were determined by a sensitive radioimmunoassay (Peninsula) and compared between groups by Student's t test, one-way analysis of variance, and linear regression analysis. Results: Plasma ET-1 concentration in severely preeclamptic women was 7.19 ± 0.97 pg/ml compared with 5.63 ± 1.3 pg/ml in the control group (P < 0.05) . ET-1 levels did not decrease significantly 24 h postpartum in either the group with severe preeclampsia (7.19 ± 0.79 vs 7.02 ± 1.34 pg/ml; P > 0.05) or in the laboring normotensive controls (6.12 ± 0.67 vs 6.00 ± 1.04 pg/ml; P > 0.05). ET-1 concentrations were not significantly elevated in laboring vs nonlaboring normotensives (6.12 ± 0.67 vs 5.03 ± 1.25 pg/ml; P > 0.05). Conclusions: ET-1 concentrations were significantly increased in patients with severe preeclampsia compared with normotensive gravidas, and plasma concentrations remained unchanged 24 h postdelivery.

AB - Objective: To determine the effects severe preeclampsia, labor, and parturition have on endothelin (ET-1) concentrations. Methods: Plasma immunoreactive ET-1 concentrations were studied prospectively in 36 gravidas, 13 with severe preeclampsia and 23 normotensive (9 laboring, 14 nonlaboring) controls matched for gestational age. Blood samples were collected from all severe preeclamptic and laboring normotensive control patients following hospital admission, prior to the administration of magnesium sulfate or oxytocin, and 24 h postpartum. A single sample was collected from nonlaboring outpatient control gravidas. ET-1 concentrations were determined by a sensitive radioimmunoassay (Peninsula) and compared between groups by Student's t test, one-way analysis of variance, and linear regression analysis. Results: Plasma ET-1 concentration in severely preeclamptic women was 7.19 ± 0.97 pg/ml compared with 5.63 ± 1.3 pg/ml in the control group (P < 0.05) . ET-1 levels did not decrease significantly 24 h postpartum in either the group with severe preeclampsia (7.19 ± 0.79 vs 7.02 ± 1.34 pg/ml; P > 0.05) or in the laboring normotensive controls (6.12 ± 0.67 vs 6.00 ± 1.04 pg/ml; P > 0.05). ET-1 concentrations were not significantly elevated in laboring vs nonlaboring normotensives (6.12 ± 0.67 vs 5.03 ± 1.25 pg/ml; P > 0.05). Conclusions: ET-1 concentrations were significantly increased in patients with severe preeclampsia compared with normotensive gravidas, and plasma concentrations remained unchanged 24 h postdelivery.

UR - http://www.scopus.com/inward/record.url?scp=0028114006&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028114006&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0028114006

VL - 4

SP - 129

EP - 132

JO - Journal of Maternal-Fetal Investigation

JF - Journal of Maternal-Fetal Investigation

SN - 0939-6322

IS - 3

ER -