The immunology of smallpox vaccines

Richard B Kennedy, Inna G. Ovsyannikova, Robert M. Jacobson, Gregory A. Poland

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

In spite of the eradication of smallpox over 30 years ago; orthopox viruses such as smallpox and monkeypox remain serious public health threats both through the possibility of bioterrorism and the intentional release of smallpox and through natural outbreaks of emerging infectious diseases such as monkeypox. The eradication effort was largely made possible by the availability of an effective vaccine based on the immunologically cross-protective vaccinia virus. Although the concept of vaccination dates back to the late 1800s with Edward Jenner, it is only in the past decade that modern immunologic tools have been applied toward deciphering poxvirus immunity. Smallpox vaccines containing vaccinia virus elicit strong humoral and cellular immune responses that confer cross-protective immunity against variola virus for decades after immunization. Recent studies have focused on: establishing the longevity of poxvirus-specific immunity, defining key immune epitopes targeted by T and B cells, developing subunit-based vaccines, and developing genotypic and phenotypic immune response profiles that predict either vaccine response or adverse events following immunization.

Original languageEnglish (US)
Pages (from-to)314-320
Number of pages7
JournalCurrent Opinion in Immunology
Volume21
Issue number3
DOIs
StatePublished - Jun 2009

Fingerprint

Smallpox Vaccine
Smallpox
Monkeypox
Allergy and Immunology
Poxviridae
Immunity
Vaccinia virus
Immunization
Vaccines
Variola virus
Emerging Communicable Diseases
B-Lymphocyte Epitopes
Bioterrorism
Subunit Vaccines
T-Lymphocyte Epitopes
Humoral Immunity
Cellular Immunity
Disease Outbreaks
Vaccination
Public Health

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Kennedy, R. B., Ovsyannikova, I. G., Jacobson, R. M., & Poland, G. A. (2009). The immunology of smallpox vaccines. Current Opinion in Immunology, 21(3), 314-320. https://doi.org/10.1016/j.coi.2009.04.004

The immunology of smallpox vaccines. / Kennedy, Richard B; Ovsyannikova, Inna G.; Jacobson, Robert M.; Poland, Gregory A.

In: Current Opinion in Immunology, Vol. 21, No. 3, 06.2009, p. 314-320.

Research output: Contribution to journalArticle

Kennedy, RB, Ovsyannikova, IG, Jacobson, RM & Poland, GA 2009, 'The immunology of smallpox vaccines', Current Opinion in Immunology, vol. 21, no. 3, pp. 314-320. https://doi.org/10.1016/j.coi.2009.04.004
Kennedy, Richard B ; Ovsyannikova, Inna G. ; Jacobson, Robert M. ; Poland, Gregory A. / The immunology of smallpox vaccines. In: Current Opinion in Immunology. 2009 ; Vol. 21, No. 3. pp. 314-320.
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