TY - JOUR
T1 - The Hypothalamus and Pituitary in Cerebral Gigantism
T2 - A Clinicopathologic and Immunocytochemical Study
AU - Whitaker, Michael D.
AU - Scheithauer, Bernd W.
AU - Hayles, Alvin B.
AU - Okazaki, Haruo
PY - 1985/7
Y1 - 1985/7
N2 - Cerebral glgantism, or Sotos’ disease, is a rare disorder of unknown cause characterized by the early onset of excessive growth, acromegallc features, and some degree of mental retardation. Although several endocrinologic abnormalities have been described in such patients, none has been specific or sufficient to explain the clinical features. Our report of the endocrinologic and pathologic aspects in a young woman with Sotos’ disease includes the first microanatomic study of the hypothalamus and Immunocytochemical examination of the pituitary gland in this disorder.
AB - Cerebral glgantism, or Sotos’ disease, is a rare disorder of unknown cause characterized by the early onset of excessive growth, acromegallc features, and some degree of mental retardation. Although several endocrinologic abnormalities have been described in such patients, none has been specific or sufficient to explain the clinical features. Our report of the endocrinologic and pathologic aspects in a young woman with Sotos’ disease includes the first microanatomic study of the hypothalamus and Immunocytochemical examination of the pituitary gland in this disorder.
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U2 - 10.1001/archpedi.1985.02140090041023
DO - 10.1001/archpedi.1985.02140090041023
M3 - Article
C2 - 4014090
AN - SCOPUS:0021843894
SN - 0002-922X
VL - 139
SP - 679
EP - 682
JO - American Journal of Diseases of Children
JF - American Journal of Diseases of Children
IS - 7
ER -