The hypothalamus and pituitary in cerebral gigantism. A clinicopathologic and immunocytochemical study

M. D. Whitaker, B. W. Scheithauer, A. B. Hayles, H. Okazaki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cerebral gigantism, or Sotos' disease, is a rare disorder of unknown cause characterized by the early onset of excessive growth, acromegalic features, and some degree of mental retardation. Although several endocrinologic abnormalities have been described in such patients, none has been specific or sufficient to explain the clinical features. Our report of the endocrinologic and pathologic aspects in a young woman with Sotos' disease includes the first microanatomic study of the hypothalamus and immunocytochemical examination of the pituitary gland in this disorder.

Original languageEnglish (US)
Pages (from-to)679-682
Number of pages4
JournalAmerican Journal of Diseases of Children
Volume139
Issue number7
StatePublished - 1985

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Sotos Syndrome
Hypothalamus
Pituitary Gland
Intellectual Disability
Growth

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Whitaker, M. D., Scheithauer, B. W., Hayles, A. B., & Okazaki, H. (1985). The hypothalamus and pituitary in cerebral gigantism. A clinicopathologic and immunocytochemical study. American Journal of Diseases of Children, 139(7), 679-682.

The hypothalamus and pituitary in cerebral gigantism. A clinicopathologic and immunocytochemical study. / Whitaker, M. D.; Scheithauer, B. W.; Hayles, A. B.; Okazaki, H.

In: American Journal of Diseases of Children, Vol. 139, No. 7, 1985, p. 679-682.

Research output: Contribution to journalArticle

Whitaker, MD, Scheithauer, BW, Hayles, AB & Okazaki, H 1985, 'The hypothalamus and pituitary in cerebral gigantism. A clinicopathologic and immunocytochemical study', American Journal of Diseases of Children, vol. 139, no. 7, pp. 679-682.
Whitaker, M. D. ; Scheithauer, B. W. ; Hayles, A. B. ; Okazaki, H. / The hypothalamus and pituitary in cerebral gigantism. A clinicopathologic and immunocytochemical study. In: American Journal of Diseases of Children. 1985 ; Vol. 139, No. 7. pp. 679-682.
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