The H-2 haplotype of the PN (Palmerston North) inbred strain

J. S. Schultz, S. E. Walker, C. S. David

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Inbred Palmerston North (PN) mice have been established as an animal model of the multisystem autoimmune disease, systemic lupus erythematosus. Disease in these animals is characterized by the presence of antibodies to nuclear antigens and immune-complex glomerulonephritis. Because of the usefulness of this animal model for further studies of autoimmune disease, and because of the well-known relationship between the major histocompatibility complex (MHC) and autoimmuno-disease development, it is of considerable interest to determine the H-2 haplotype carried by this strain. To accomplish this identification, antigens in the K, D, and I regions of the MHC were determined by microcytotoxic assay.

Original languageEnglish (US)
Pages (from-to)269-271
Number of pages3
JournalImmunogenetics
Volume16
Issue number3
StatePublished - 1982

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Major Histocompatibility Complex
Haplotypes
Autoimmune Diseases
Animal Models
Nuclear Antigens
Animal Diseases
Glomerulonephritis
Antigen-Antibody Complex
Systemic Lupus Erythematosus
Antibodies
K antigens

ASJC Scopus subject areas

  • Genetics
  • Immunology

Cite this

Schultz, J. S., Walker, S. E., & David, C. S. (1982). The H-2 haplotype of the PN (Palmerston North) inbred strain. Immunogenetics, 16(3), 269-271.

The H-2 haplotype of the PN (Palmerston North) inbred strain. / Schultz, J. S.; Walker, S. E.; David, C. S.

In: Immunogenetics, Vol. 16, No. 3, 1982, p. 269-271.

Research output: Contribution to journalArticle

Schultz, JS, Walker, SE & David, CS 1982, 'The H-2 haplotype of the PN (Palmerston North) inbred strain', Immunogenetics, vol. 16, no. 3, pp. 269-271.
Schultz JS, Walker SE, David CS. The H-2 haplotype of the PN (Palmerston North) inbred strain. Immunogenetics. 1982;16(3):269-271.
Schultz, J. S. ; Walker, S. E. ; David, C. S. / The H-2 haplotype of the PN (Palmerston North) inbred strain. In: Immunogenetics. 1982 ; Vol. 16, No. 3. pp. 269-271.
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