TY - JOUR
T1 - The Genitourinary Pathology Society Update on Classification of Variant Histologies, T1 Substaging, Molecular Taxonomy, and Immunotherapy and PD-L1 Testing Implications of Urothelial Cancers
AU - Compérat, Eva
AU - Amin, Mahul B.
AU - Epstein, Jonathan I.
AU - Hansel, Donna E.
AU - Paner, Gladell
AU - Al-Ahmadie, Hikmat
AU - True, Larry
AU - Bayder, DIlek
AU - Bivalacqua, Trinity
AU - Brimo, Fadi
AU - Cheng, Liang
AU - Cheville, John
AU - Dalbagni, Guido
AU - Falzarano, Sara
AU - Gordetsky, Jennifer
AU - Guo, Charles
AU - Gupta, Sounak
AU - Hes, Ondrej
AU - Iyer, Gopa
AU - Kaushal, Seema
AU - Kunju, Lakshmi
AU - Magi-Galluzzi, Cristina
AU - Matoso, Andres
AU - McKenney, Jesse
AU - Netto, George J.
AU - Osunkoya, Adeboye O.
AU - Pan, Chin Chen
AU - Pivovarcikova, Kristina
AU - Raspollini, Maria R.
AU - Reis, Henning
AU - Rosenberg, Jonathan
AU - Roupret, Morgan
AU - Shah, Rajal B.
AU - Shariat, Shahrokh F.
AU - Trpkov, Kiril
AU - Weyerer, Veronika
AU - Zhou, Ming
AU - Reuter, Victor
N1 - Publisher Copyright:
© 2021 Lippincott Williams and Wilkins. All rights reserved.
PY - 2021/7
Y1 - 2021/7
N2 - The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in bladder cancer focusing on important topics of high interest for the practicing surgical pathologist and urologist. This review represents the second of 2 manuscripts ensuing from this effort. Herein, we address the effective reporting of bladder cancer, focusing particularly on newly published data since the last 2016 World Health Organization (WHO) classification. In addition, this review focuses on the importance of reporting bladder cancer with divergent differentiation and variant (subtypes of urothelial carcinoma) histologies and the potential impact on patient care. We provide new recommendations for reporting pT1 staging in diagnostic pathology. Furthermore, we explore molecular evolution and classification, emphasizing aspects that impact the understanding of important concepts relevant to reporting and management of patients.
AB - The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in bladder cancer focusing on important topics of high interest for the practicing surgical pathologist and urologist. This review represents the second of 2 manuscripts ensuing from this effort. Herein, we address the effective reporting of bladder cancer, focusing particularly on newly published data since the last 2016 World Health Organization (WHO) classification. In addition, this review focuses on the importance of reporting bladder cancer with divergent differentiation and variant (subtypes of urothelial carcinoma) histologies and the potential impact on patient care. We provide new recommendations for reporting pT1 staging in diagnostic pathology. Furthermore, we explore molecular evolution and classification, emphasizing aspects that impact the understanding of important concepts relevant to reporting and management of patients.
KW - WHO classification
KW - bladder cancer
KW - immunotherapy
KW - molecular classification of bladder cancer
KW - pTNM
KW - pathology
KW - stage
KW - subtypes
KW - urothelial carcinoma
KW - variant histology
UR - http://www.scopus.com/inward/record.url?scp=85108193665&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85108193665&partnerID=8YFLogxK
U2 - 10.1097/PAP.0000000000000309
DO - 10.1097/PAP.0000000000000309
M3 - Review article
C2 - 34128484
AN - SCOPUS:85108193665
SN - 1072-4109
VL - 28
SP - 196
EP - 208
JO - Advances in anatomic pathology
JF - Advances in anatomic pathology
IS - 4
ER -