The general anesthesia induced by various drugs differentially affects analgesia and its variability

William A. Banks, Terrence L. Trentman, Abba J. Kastin, Z. Harry Galina

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Responses to noxious stimuli in awake animals are not totally consensual but are influenced by environmental factors. We considered the possibility that the influence of the environment could be reduced by induction of general anesthesia. We, therefore, compared responses to nociceptive thermal stimuli by measuring tail flick latency, a spinal reflex, in anesthetized and awake mice. All anesthetics tested decreased the intraindividual variability in the measurement of response, suggesting that environmental factors may account for much of this variability in the awake mouse. Mice treated with pentobarbital showed a graded response to increasing levels of heat but were unresponsive to either morphine or naloxone. In mice anesthetized with pentobarbital, increases in latencies occured only at very deep levels of anesthesia, while urethane increased and ketamine decreased latencies. The antinociceptive effect of urethane was unaffected by naloxone, but the nociceptive effect of ketamine was reversed by morphine. Thus, the various anesthetics could show differential effects towards opiate action. The decrease in statistical variability, the differential effects of general anesthetics on tail flick latency, and the distinctive effects of the different anesthetics on opiate action suggest that the anesthetized animal may be a useful tool in the study of nociception.

Original languageEnglish (US)
Pages (from-to)397-403
Number of pages7
JournalPharmacology, Biochemistry and Behavior
Volume31
Issue number2
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Opiate Alkaloids
Analgesia
General Anesthesia
Anesthetics
Urethane
Ketamine
Pentobarbital
Naloxone
Morphine
Animals
Pharmaceutical Preparations
Tail
General Anesthetics
Hot Temperature
Nociception
Reflex
Anesthesia

Keywords

  • Analgesia
  • Anesthesia
  • Ketamine
  • Morphine
  • Naloxone
  • Nociception
  • Opiate receptors
  • Opiates
  • Pentobarbital
  • Urethane

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

The general anesthesia induced by various drugs differentially affects analgesia and its variability. / Banks, William A.; Trentman, Terrence L.; Kastin, Abba J.; Galina, Z. Harry.

In: Pharmacology, Biochemistry and Behavior, Vol. 31, No. 2, 1988, p. 397-403.

Research output: Contribution to journalArticle

Banks, William A. ; Trentman, Terrence L. ; Kastin, Abba J. ; Galina, Z. Harry. / The general anesthesia induced by various drugs differentially affects analgesia and its variability. In: Pharmacology, Biochemistry and Behavior. 1988 ; Vol. 31, No. 2. pp. 397-403.
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