The feline herpesvirus type 1 ICP4 down-regulates feline immunodeficiency virus long terminal repeat(LTR)-directed gene expression via the C/EBP site in the LTR

Yasushi Kawaguchi, Ken Maeda, Marcelo R. Pecoraro, Yasuo Inoshima, Hyung kwan Jang, Mariko Kohmoto, Kiyoko Iwatsuki, Yasuhiro Ikeda, Masahiro Shimojima, Yukinobu Tohya, Chieko Kai, Takeshi Mikami

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We investigated effects of feline herpesvirus type 1 (FHV-1) ICP4 on feline immunodeficiency virus (FIV) long terminal repeat (LTR)-directed gene expression by transient transfection assay in Crandell feline kidney cells. We demonstrated that FHV-1 ICP4 significantly stimulates the FIV LTR after introduction of site-specific mutation of the C/EBP site in the LTR, and the C/EBP site is sufficient to confer inhibitory effects by FHV-1 ICP4 on a heterologous promoter. These results indicate that FHV-1 ICP4 possesses both ability to transactivate FIV LTR-directed gene expression and to down-regulate the FIV LTR via the C/EBP site.

Original languageEnglish (US)
Pages (from-to)1129-1131
Number of pages3
JournalJournal of Veterinary Medical Science
Volume57
Issue number6
DOIs
StatePublished - 1995

Keywords

  • C/EBP site
  • FHV-1 ICP4
  • FIV LTR

ASJC Scopus subject areas

  • veterinary(all)

Fingerprint Dive into the research topics of 'The feline herpesvirus type 1 ICP4 down-regulates feline immunodeficiency virus long terminal repeat(LTR)-directed gene expression via the C/EBP site in the LTR'. Together they form a unique fingerprint.

Cite this