TY - JOUR
T1 - The essential roles of transition fibers in the context of cilia
AU - Wei, Qing
AU - Ling, Kun
AU - Hu, Jinghua
N1 - Funding Information:
We thank our many colleagues who have contributed to the work described herein, and apologize to those whose work we could not cite due to the space issue. We are grateful for funding from the National Institutes of Health research grant 1R01DK090038 , 1R01DK099160-01A1 , and P30 center grant P30DK90728 . K.L. was supported by the National Cancer Institute (NCI; 1R01CA149039-01A1 ), Susan G. Komen for the Cure ( KG100902 ).
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Once thought of as a vestigial organelle, the primary cilium is now recognized as a signaling hub for key cellular pathways in vertebrate development. The recent renaissance in cilia studies significantly improved our understanding of how cilia form and function, but little is known about how ciliogenesis is initiated and how ciliary proteins enter cilia. These important ciliary events require transition fibers (TFs) that are positioned at the ciliary base as symmetric nine-bladed propeller fibrous structures. Up until recently, TFs have been the most underappreciated ciliary structures due to limited knowledge about their molecular composition and function. Here, we highlight recent advances in our understanding of TF composition and the indispensable roles of TFs in regulating the initiation of ciliogenesis and the selective import of ciliary proteins.
AB - Once thought of as a vestigial organelle, the primary cilium is now recognized as a signaling hub for key cellular pathways in vertebrate development. The recent renaissance in cilia studies significantly improved our understanding of how cilia form and function, but little is known about how ciliogenesis is initiated and how ciliary proteins enter cilia. These important ciliary events require transition fibers (TFs) that are positioned at the ciliary base as symmetric nine-bladed propeller fibrous structures. Up until recently, TFs have been the most underappreciated ciliary structures due to limited knowledge about their molecular composition and function. Here, we highlight recent advances in our understanding of TF composition and the indispensable roles of TFs in regulating the initiation of ciliogenesis and the selective import of ciliary proteins.
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U2 - 10.1016/j.ceb.2015.04.015
DO - 10.1016/j.ceb.2015.04.015
M3 - Review article
C2 - 25988548
AN - SCOPUS:84938683916
VL - 35
SP - 98
EP - 105
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
ER -