The essential roles of transition fibers in the context of cilia

Qing Wei, Kun Ling, Jinghua Hu

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Once thought of as a vestigial organelle, the primary cilium is now recognized as a signaling hub for key cellular pathways in vertebrate development. The recent renaissance in cilia studies significantly improved our understanding of how cilia form and function, but little is known about how ciliogenesis is initiated and how ciliary proteins enter cilia. These important ciliary events require transition fibers (TFs) that are positioned at the ciliary base as symmetric nine-bladed propeller fibrous structures. Up until recently, TFs have been the most underappreciated ciliary structures due to limited knowledge about their molecular composition and function. Here, we highlight recent advances in our understanding of TF composition and the indispensable roles of TFs in regulating the initiation of ciliogenesis and the selective import of ciliary proteins.

Original languageEnglish (US)
Pages (from-to)98-105
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume35
DOIs
StatePublished - Aug 1 2015

ASJC Scopus subject areas

  • Cell Biology

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