Abstract
Although the cause of multiple sclerosis (MS) is unknown, epidemiologic studies support both genetic and environmental components of susceptibility. Reports of clusters, small 'epidemics,' geographic variation in prevalence, and alteration of MS susceptibility by migration support an environmental factor (or factors). The higher risk for MS in Europeans and in relatives of patients and the existence of MS-resistant ethnic groups support genetic predisposition. Findings from epidemiologic studies are most consistent with an environmental influence occurring on a background of genetic susceptibility as the cause of MS. Currently, there is little evidence for a single or unique environmental cause of MS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 871-878 |
| Number of pages | 8 |
| Journal | Mayo Clinic Proceedings |
| Volume | 72 |
| Issue number | 9 |
| State | Published - 1997 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
The epidemiology of multiple sclerosis. / Hogancamp, William E.; Rodriguez, Moses; Weinshenker, Brian G.
In: Mayo Clinic Proceedings, Vol. 72, No. 9, 1997, p. 871-878.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The epidemiology of multiple sclerosis
AU - Hogancamp, William E.
AU - Rodriguez, Moses
AU - Weinshenker, Brian G
PY - 1997
Y1 - 1997
N2 - Although the cause of multiple sclerosis (MS) is unknown, epidemiologic studies support both genetic and environmental components of susceptibility. Reports of clusters, small 'epidemics,' geographic variation in prevalence, and alteration of MS susceptibility by migration support an environmental factor (or factors). The higher risk for MS in Europeans and in relatives of patients and the existence of MS-resistant ethnic groups support genetic predisposition. Findings from epidemiologic studies are most consistent with an environmental influence occurring on a background of genetic susceptibility as the cause of MS. Currently, there is little evidence for a single or unique environmental cause of MS.
AB - Although the cause of multiple sclerosis (MS) is unknown, epidemiologic studies support both genetic and environmental components of susceptibility. Reports of clusters, small 'epidemics,' geographic variation in prevalence, and alteration of MS susceptibility by migration support an environmental factor (or factors). The higher risk for MS in Europeans and in relatives of patients and the existence of MS-resistant ethnic groups support genetic predisposition. Findings from epidemiologic studies are most consistent with an environmental influence occurring on a background of genetic susceptibility as the cause of MS. Currently, there is little evidence for a single or unique environmental cause of MS.
UR - http://www.scopus.com/inward/record.url?scp=0030799133&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030799133&partnerID=8YFLogxK
M3 - Article
C2 - 9294536
AN - SCOPUS:0030799133
VL - 72
SP - 871
EP - 878
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
SN - 0025-6196
IS - 9
ER -