TY - JOUR
T1 - The epidemiology of multiple sclerosis
AU - Hogancamp, William E.
AU - Rodriguez, Moses
AU - Weinshenker, Brian G.
N1 - Funding Information:
Tis research was funded by grants from the Shanghai Municipal Commission of Health and Family Planning Foundation for Key Developing Disciplines (2015ZB0103) and the Shanghai Jiao Tong University Biomedical Engineering Cross Research Foundation (YG2015MS15). JVL is funded by MRC New Investigator Grant (MR/P002536/1) and ERC Starting Grant (715662).
PY - 1997
Y1 - 1997
N2 - Although the cause of multiple sclerosis (MS) is unknown, epidemiologic studies support both genetic and environmental components of susceptibility. Reports of clusters, small 'epidemics,' geographic variation in prevalence, and alteration of MS susceptibility by migration support an environmental factor (or factors). The higher risk for MS in Europeans and in relatives of patients and the existence of MS-resistant ethnic groups support genetic predisposition. Findings from epidemiologic studies are most consistent with an environmental influence occurring on a background of genetic susceptibility as the cause of MS. Currently, there is little evidence for a single or unique environmental cause of MS.
AB - Although the cause of multiple sclerosis (MS) is unknown, epidemiologic studies support both genetic and environmental components of susceptibility. Reports of clusters, small 'epidemics,' geographic variation in prevalence, and alteration of MS susceptibility by migration support an environmental factor (or factors). The higher risk for MS in Europeans and in relatives of patients and the existence of MS-resistant ethnic groups support genetic predisposition. Findings from epidemiologic studies are most consistent with an environmental influence occurring on a background of genetic susceptibility as the cause of MS. Currently, there is little evidence for a single or unique environmental cause of MS.
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U2 - 10.4065/72.9.871
DO - 10.4065/72.9.871
M3 - Article
C2 - 9294536
AN - SCOPUS:0030799133
SN - 0025-6196
VL - 72
SP - 871
EP - 878
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 9
ER -