The effects of tranexamic acid on blood loss and transfusion rate in colorectal surgery

Fabian Grass, Signe Braafladt, Jasim Alabbad, Jenna K. Lovely, Scott R. Kelley, Kellie L. Mathis, Marianne Huebner, David Larson

Research output: Contribution to journalArticle


Background: The present study aimed to evaluate safety of tranexamic acid (TA) administration and to assess bleeding risk in colorectal surgery (CRS). Methods: Retrospective cohort study including consecutive patients undergoing elective CRS by a single surgeon between August 2014 and May 2015. All patients received 1 g of TA intravenously at induction and at closure. Demographics, operative and postoperative details were prospectively assessed and compared to a historical control cohort. Results: 213 patients were evaluated. TA did not increase complications, readmissions, or reoperation rates. Significant postoperative hemoglobin (Hgb) drop (≥3 g/dL) (TA: n = 6, 7.4%, Control: n = 22, 16.6%; p = 0.193) and transfusion rates (intraoperative: TA: n = 2, 2.5%, Control: n = 2, 1.5%; p = 0.586, postoperative: TA: n = 1, 1.2%, Control: 9, 6.8%; p = 0.065) were not statistically different. Conclusions: Postoperative hemoglobin drop and transfusion rates were not decreased statistically. Further study is warranted given the large clinical differences in favor of TA. Tranexamic acid (TA) administration did not increase complications, readmissions or reoperations in this consecutive, unselected cohort of colorectal surgical patients. Postoperative hemoglobin drop and transfusion rate were not decreased statistically; however, large clinical differences in favor of TA warrant further study.

Original languageEnglish (US)
JournalAmerican journal of surgery
StatePublished - Jan 1 2019



  • Colorectal surgery
  • Patient outcomes
  • Tranexamic acid

ASJC Scopus subject areas

  • Surgery

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