The effect of walking on postprandial glycemic excursion in patients with type 1 diabetes and healthy people

Chinmay Manohar, James A. Levine, Debashis K. Nandy, Ahmed Saad, Chiara Dalla Man, Shelly K. McCrady-Spitzer, Rita Basu, Claudio Cobelli, Rickey E. Carter, Ananda Basu, Yogish C Kudva

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE - Physical activity (PA), even at low intensity, promotes health and improves hyperglycemia. However, the effect of low-intensity PA captured with accelerometery on glucose variability in healthy individuals and patients with type 1 diabetes has not been examined. Quantifying the effects of PA on glycemic variability would improve artificial endocrine pancreas (AEP) algorithms. RESEARCH DESIGN AND METHODS - We studied 12 healthy control subjects (five males, 37.7 ± 13.7 years of age) and 12 patients with type 1 diabetes (five males, 37.4 ± 14.2 years of age) for 88 h. Participants performed PA approximating a threefold increase over their basalmetabolic rate. PAwas captured using a PA-monitoring system, and interstitial fluid glucose concentrations were captured with continuous glucose monitors. In randomorder, one meal per day was followed by inactivity, and the other meals were followed by walking. Glucose and PA data for a total of 216 meals were analyzed from 30 min prior to meal ingestion to 270 min postmeal. RESULTS - In healthy subjects, the incremental glucose area under the curve was 4.5mmol/L/270min for meals followed by walking, whereas it was 9.6mmol/L/270 min (P = 0.022) for meals followed by inactivity. The corresponding glucose excursions for those with type 1 diabetes were 7.5 mmol/L/270 min and 18.4 mmol/L/270 min, respectively (P < 0.001). CONCLUSIONS - Walking significantly impacts postprandial glucose excursions in healthy populations and in those with type 1 diabetes. AEP algorithms incorporating PA may enhance tight glycemic control end points.

Original languageEnglish (US)
Pages (from-to)2493-2499
Number of pages7
JournalDiabetes Care
Volume35
Issue number12
DOIs
StatePublished - Dec 2012

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Type 1 Diabetes Mellitus
Walking
Meals
Exercise
Glucose
Insulin Infusion Systems
Healthy Volunteers
Extracellular Fluid
Hyperglycemia
Area Under Curve
Research Design
Eating
Health
Population

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Manohar, C., Levine, J. A., Nandy, D. K., Saad, A., Man, C. D., McCrady-Spitzer, S. K., ... Kudva, Y. C. (2012). The effect of walking on postprandial glycemic excursion in patients with type 1 diabetes and healthy people. Diabetes Care, 35(12), 2493-2499. https://doi.org/10.2337/dc11-2381

The effect of walking on postprandial glycemic excursion in patients with type 1 diabetes and healthy people. / Manohar, Chinmay; Levine, James A.; Nandy, Debashis K.; Saad, Ahmed; Man, Chiara Dalla; McCrady-Spitzer, Shelly K.; Basu, Rita; Cobelli, Claudio; Carter, Rickey E.; Basu, Ananda; Kudva, Yogish C.

In: Diabetes Care, Vol. 35, No. 12, 12.2012, p. 2493-2499.

Research output: Contribution to journalArticle

Manohar, C, Levine, JA, Nandy, DK, Saad, A, Man, CD, McCrady-Spitzer, SK, Basu, R, Cobelli, C, Carter, RE, Basu, A & Kudva, YC 2012, 'The effect of walking on postprandial glycemic excursion in patients with type 1 diabetes and healthy people', Diabetes Care, vol. 35, no. 12, pp. 2493-2499. https://doi.org/10.2337/dc11-2381
Manohar C, Levine JA, Nandy DK, Saad A, Man CD, McCrady-Spitzer SK et al. The effect of walking on postprandial glycemic excursion in patients with type 1 diabetes and healthy people. Diabetes Care. 2012 Dec;35(12):2493-2499. https://doi.org/10.2337/dc11-2381
Manohar, Chinmay ; Levine, James A. ; Nandy, Debashis K. ; Saad, Ahmed ; Man, Chiara Dalla ; McCrady-Spitzer, Shelly K. ; Basu, Rita ; Cobelli, Claudio ; Carter, Rickey E. ; Basu, Ananda ; Kudva, Yogish C. / The effect of walking on postprandial glycemic excursion in patients with type 1 diabetes and healthy people. In: Diabetes Care. 2012 ; Vol. 35, No. 12. pp. 2493-2499.
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AU - Levine, James A.

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AU - Saad, Ahmed

AU - Man, Chiara Dalla

AU - McCrady-Spitzer, Shelly K.

AU - Basu, Rita

AU - Cobelli, Claudio

AU - Carter, Rickey E.

AU - Basu, Ananda

AU - Kudva, Yogish C

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N2 - OBJECTIVE - Physical activity (PA), even at low intensity, promotes health and improves hyperglycemia. However, the effect of low-intensity PA captured with accelerometery on glucose variability in healthy individuals and patients with type 1 diabetes has not been examined. Quantifying the effects of PA on glycemic variability would improve artificial endocrine pancreas (AEP) algorithms. RESEARCH DESIGN AND METHODS - We studied 12 healthy control subjects (five males, 37.7 ± 13.7 years of age) and 12 patients with type 1 diabetes (five males, 37.4 ± 14.2 years of age) for 88 h. Participants performed PA approximating a threefold increase over their basalmetabolic rate. PAwas captured using a PA-monitoring system, and interstitial fluid glucose concentrations were captured with continuous glucose monitors. In randomorder, one meal per day was followed by inactivity, and the other meals were followed by walking. Glucose and PA data for a total of 216 meals were analyzed from 30 min prior to meal ingestion to 270 min postmeal. RESULTS - In healthy subjects, the incremental glucose area under the curve was 4.5mmol/L/270min for meals followed by walking, whereas it was 9.6mmol/L/270 min (P = 0.022) for meals followed by inactivity. The corresponding glucose excursions for those with type 1 diabetes were 7.5 mmol/L/270 min and 18.4 mmol/L/270 min, respectively (P < 0.001). CONCLUSIONS - Walking significantly impacts postprandial glucose excursions in healthy populations and in those with type 1 diabetes. AEP algorithms incorporating PA may enhance tight glycemic control end points.

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