The effect of preoperative flurbiprofen on miosis produced by acetylcholine during cataract surgery

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Sustained pupillary dilation during cataract surgery may be achieved with preoperative noncorticosteroidal anti-inflammatory agents such as flurbiprofen. However, these agents may interfere with miosis after injection of acetylcholine. Thirty patients for extracapsular cataract extraction were randomly assigned in a double-masked fashion to receive either a placebo or preoperative 0.03% flurbiprofen every 30 minutes for four doses. All patients also received three doses of 2.5% phenylephrine and 2% cyclopentolate. Pupillary diameter was measured the day before surgery, immediately before the surgical incision, immediately before and five minutes after acetylcholine injection, and the morning after surgery. The flurbiprofen group had a larger mean pupillary diameter before injection of acetylcholine (P < .001), five minutes after acetylcholine (P < .001), and on the first postoperative day (P < .005).

Original languageEnglish (US)
Pages (from-to)735-738
Number of pages4
JournalAmerican Journal of Ophthalmology
Volume111
Issue number6
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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