The Effect of Long‐Term: Opiate Antagonist Administration to Pubertal Boys

HOWARD E. KULIN, LAURENCE M. DEMERS, ALAN D. ROGOL, JOHANNES D. VELDHUIS

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

To test further the hypothesis that opiatergic pathways controlling gonadotropin production may be functional during early to mid adolescence, nine pubertal boys with bone ages ranging from 10 to 15 were given the long‐acting opiate antagonist, naltrexone, for up to 4 weeks. Urinary gonadotropin measurements were assessed before, during, and after drug administration. In three early to mid‐pubertal boys who received naltrexone for 3 to 4 weeks, LRH testing was also performed. No evidence of a stimulatory FSH or LH response to naltrexone was found in any of the patients evaluated. The data do not support the operation of an opiate‐mediated mechanism in the control of pubertal onset in man. 1987 American Society of Andrology

Original languageEnglish (US)
Pages (from-to)374-377
Number of pages4
JournalJournal of Andrology
Volume8
Issue number6
DOIs
StatePublished - Jan 1 1987

Keywords

  • Puberty
  • opiate control of gonadotropins

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Urology

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    KULIN, HOWARD. E., DEMERS, LAURENCE. M., ROGOL, ALAN. D., & VELDHUIS, JOHANNES. D. (1987). The Effect of Long‐Term: Opiate Antagonist Administration to Pubertal Boys. Journal of Andrology, 8(6), 374-377. https://doi.org/10.1002/j.1939-4640.1987.tb00980.x