TY - JOUR
T1 - The Effect of Long‐Term
T2 - Opiate Antagonist Administration to Pubertal Boys
AU - KULIN, HOWARD E.
AU - DEMERS, LAURENCE M.
AU - ROGOL, ALAN D.
AU - VELDHUIS, JOHANNES D.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1987
Y1 - 1987
N2 - To test further the hypothesis that opiatergic pathways controlling gonadotropin production may be functional during early to mid adolescence, nine pubertal boys with bone ages ranging from 10 to 15 were given the long‐acting opiate antagonist, naltrexone, for up to 4 weeks. Urinary gonadotropin measurements were assessed before, during, and after drug administration. In three early to mid‐pubertal boys who received naltrexone for 3 to 4 weeks, LRH testing was also performed. No evidence of a stimulatory FSH or LH response to naltrexone was found in any of the patients evaluated. The data do not support the operation of an opiate‐mediated mechanism in the control of pubertal onset in man. 1987 American Society of Andrology
AB - To test further the hypothesis that opiatergic pathways controlling gonadotropin production may be functional during early to mid adolescence, nine pubertal boys with bone ages ranging from 10 to 15 were given the long‐acting opiate antagonist, naltrexone, for up to 4 weeks. Urinary gonadotropin measurements were assessed before, during, and after drug administration. In three early to mid‐pubertal boys who received naltrexone for 3 to 4 weeks, LRH testing was also performed. No evidence of a stimulatory FSH or LH response to naltrexone was found in any of the patients evaluated. The data do not support the operation of an opiate‐mediated mechanism in the control of pubertal onset in man. 1987 American Society of Andrology
KW - Puberty
KW - opiate control of gonadotropins
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U2 - 10.1002/j.1939-4640.1987.tb00980.x
DO - 10.1002/j.1939-4640.1987.tb00980.x
M3 - Article
C2 - 3123447
AN - SCOPUS:0023489345
VL - 8
SP - 374
EP - 377
JO - Journal of Andrology
JF - Journal of Andrology
SN - 0196-3635
IS - 6
ER -