The Effect of Corneal Light Scatter on Vision After Penetrating Keratoplasty

Sanjay V. Patel, Jay W. McLaren, David O. Hodge, William M. Bourne

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Purpose: To determine the effect of corneal light scatter on vision after penetrating keratoplasty (PK). Design: Cross-sectional study. Methods: setting: Cornea service at Mayo Clinic, Rochester, Minnesota. study population: Sixty-one eyes with clear grafts at 14.6 ± 10.5 years after PK; 12 eyes with late endothelial failure (LEF) at 19.7 ± 6.4 years after PK; 41 normal eyes. observation procedures: PK. main outcome measures: Backscatter from different depths of the cornea was measured by a custom scatterometer; intraocular forward light scatter was measured with a stray light meter; high-contrast visual acuity (HCVA) was measured by Early Treatment Diabetic Retinopathy Study (ETDRS) or Snellen chart; mesopic and photopic low-contrast visual acuity (LCVA) were measured with a 10% contrast chart. Results: Backscatter from the anterior, middle (stroma), and posterior thirds of the cornea was higher in clear grafts compared with normal (P < .001), and higher in grafts with LEF compared with clear grafts (P < .001). Corneal stromal backscatter from clear grafts correlated with time after keratoplasty (r = 0.21; P = .006; n = 61). Forward light scatter was higher in eyes with clear grafts compared with normal (P ≤ .006), and higher in eyes with LEF compared with clear grafts (P ≤ .01). Corneal stromal backscatter from clear grafts correlated with HCVA (r = 0.34; P = .02; n = 52), mesopic LCVA (r = 0.36; P = .01; n = 28), and photopic LCVA (r = 0.57; P < .001; n = 28). Forward scatter in eyes with clear grafts correlated with photopic LCVA (r = 0.38; P = .04; n = 26). Conclusions: Light scattered from the cornea increases with time after PK and is associated with decreased high- and low-contrast vision.

Original languageEnglish (US)
Pages (from-to)913-919
Number of pages7
JournalAmerican Journal of Ophthalmology
Volume146
Issue number6
DOIs
StatePublished - Dec 2008

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Penetrating Keratoplasty
Transplants
Light
Visual Acuity
Naphazoline
Cornea
Low Vision
Corneal Transplantation
Diabetic Retinopathy
Cross-Sectional Studies
Observation
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

Cite this

The Effect of Corneal Light Scatter on Vision After Penetrating Keratoplasty. / Patel, Sanjay V.; McLaren, Jay W.; Hodge, David O.; Bourne, William M.

In: American Journal of Ophthalmology, Vol. 146, No. 6, 12.2008, p. 913-919.

Research output: Contribution to journalArticle

Patel, Sanjay V. ; McLaren, Jay W. ; Hodge, David O. ; Bourne, William M. / The Effect of Corneal Light Scatter on Vision After Penetrating Keratoplasty. In: American Journal of Ophthalmology. 2008 ; Vol. 146, No. 6. pp. 913-919.
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abstract = "Purpose: To determine the effect of corneal light scatter on vision after penetrating keratoplasty (PK). Design: Cross-sectional study. Methods: setting: Cornea service at Mayo Clinic, Rochester, Minnesota. study population: Sixty-one eyes with clear grafts at 14.6 ± 10.5 years after PK; 12 eyes with late endothelial failure (LEF) at 19.7 ± 6.4 years after PK; 41 normal eyes. observation procedures: PK. main outcome measures: Backscatter from different depths of the cornea was measured by a custom scatterometer; intraocular forward light scatter was measured with a stray light meter; high-contrast visual acuity (HCVA) was measured by Early Treatment Diabetic Retinopathy Study (ETDRS) or Snellen chart; mesopic and photopic low-contrast visual acuity (LCVA) were measured with a 10{\%} contrast chart. Results: Backscatter from the anterior, middle (stroma), and posterior thirds of the cornea was higher in clear grafts compared with normal (P < .001), and higher in grafts with LEF compared with clear grafts (P < .001). Corneal stromal backscatter from clear grafts correlated with time after keratoplasty (r = 0.21; P = .006; n = 61). Forward light scatter was higher in eyes with clear grafts compared with normal (P ≤ .006), and higher in eyes with LEF compared with clear grafts (P ≤ .01). Corneal stromal backscatter from clear grafts correlated with HCVA (r = 0.34; P = .02; n = 52), mesopic LCVA (r = 0.36; P = .01; n = 28), and photopic LCVA (r = 0.57; P < .001; n = 28). Forward scatter in eyes with clear grafts correlated with photopic LCVA (r = 0.38; P = .04; n = 26). Conclusions: Light scattered from the cornea increases with time after PK and is associated with decreased high- and low-contrast vision.",
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AB - Purpose: To determine the effect of corneal light scatter on vision after penetrating keratoplasty (PK). Design: Cross-sectional study. Methods: setting: Cornea service at Mayo Clinic, Rochester, Minnesota. study population: Sixty-one eyes with clear grafts at 14.6 ± 10.5 years after PK; 12 eyes with late endothelial failure (LEF) at 19.7 ± 6.4 years after PK; 41 normal eyes. observation procedures: PK. main outcome measures: Backscatter from different depths of the cornea was measured by a custom scatterometer; intraocular forward light scatter was measured with a stray light meter; high-contrast visual acuity (HCVA) was measured by Early Treatment Diabetic Retinopathy Study (ETDRS) or Snellen chart; mesopic and photopic low-contrast visual acuity (LCVA) were measured with a 10% contrast chart. Results: Backscatter from the anterior, middle (stroma), and posterior thirds of the cornea was higher in clear grafts compared with normal (P < .001), and higher in grafts with LEF compared with clear grafts (P < .001). Corneal stromal backscatter from clear grafts correlated with time after keratoplasty (r = 0.21; P = .006; n = 61). Forward light scatter was higher in eyes with clear grafts compared with normal (P ≤ .006), and higher in eyes with LEF compared with clear grafts (P ≤ .01). Corneal stromal backscatter from clear grafts correlated with HCVA (r = 0.34; P = .02; n = 52), mesopic LCVA (r = 0.36; P = .01; n = 28), and photopic LCVA (r = 0.57; P < .001; n = 28). Forward scatter in eyes with clear grafts correlated with photopic LCVA (r = 0.38; P = .04; n = 26). Conclusions: Light scattered from the cornea increases with time after PK and is associated with decreased high- and low-contrast vision.

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