TY - JOUR
T1 - The Effect of Corneal Light Scatter on Vision After Penetrating Keratoplasty
AU - Patel, Sanjay V.
AU - McLaren, Jay W.
AU - Hodge, David O.
AU - Bourne, William M.
N1 - Funding Information:
This study was supported in part by National Institutes of Health Grant EY02037, Bethesda, Maryland; Research to Prevent Blindness Inc, New York, New York (Dr Patel is an Olga Keith Wiess Special Scholar and the Department of Ophthalmology, Mayo Clinic received a unrestricted Grant.); and Mayo Foundation, Rochester, Minnesota. The authors indicate no financial conflict of interest. Involved in design of study (S.V.P., J.W.M., D.O.H., W.M.B.); conduct of study (S.V.P., J.W.M., W.M.B.); collection (S.V.P., J.W.M., W.M.B.); management, analysis, and interpretation of the data (S.V.P., J.W.M., D.O.H., W.M.B.); preparation, review and approval of the manuscript (S.V.P., J.W.M., D.O.H., W.M.B.). The study was approved by the Mayo Clinic Institutional Review Board, was in compliance with the Health Information Portability and Accountability Acts (HIPAA), and adhered to the tenets of the Declaration of Helsinki. Informed consent was obtained from all study participants.
PY - 2008/12
Y1 - 2008/12
N2 - Purpose: To determine the effect of corneal light scatter on vision after penetrating keratoplasty (PK). Design: Cross-sectional study. Methods: setting: Cornea service at Mayo Clinic, Rochester, Minnesota. study population: Sixty-one eyes with clear grafts at 14.6 ± 10.5 years after PK; 12 eyes with late endothelial failure (LEF) at 19.7 ± 6.4 years after PK; 41 normal eyes. observation procedures: PK. main outcome measures: Backscatter from different depths of the cornea was measured by a custom scatterometer; intraocular forward light scatter was measured with a stray light meter; high-contrast visual acuity (HCVA) was measured by Early Treatment Diabetic Retinopathy Study (ETDRS) or Snellen chart; mesopic and photopic low-contrast visual acuity (LCVA) were measured with a 10% contrast chart. Results: Backscatter from the anterior, middle (stroma), and posterior thirds of the cornea was higher in clear grafts compared with normal (P < .001), and higher in grafts with LEF compared with clear grafts (P < .001). Corneal stromal backscatter from clear grafts correlated with time after keratoplasty (r = 0.21; P = .006; n = 61). Forward light scatter was higher in eyes with clear grafts compared with normal (P ≤ .006), and higher in eyes with LEF compared with clear grafts (P ≤ .01). Corneal stromal backscatter from clear grafts correlated with HCVA (r = 0.34; P = .02; n = 52), mesopic LCVA (r = 0.36; P = .01; n = 28), and photopic LCVA (r = 0.57; P < .001; n = 28). Forward scatter in eyes with clear grafts correlated with photopic LCVA (r = 0.38; P = .04; n = 26). Conclusions: Light scattered from the cornea increases with time after PK and is associated with decreased high- and low-contrast vision.
AB - Purpose: To determine the effect of corneal light scatter on vision after penetrating keratoplasty (PK). Design: Cross-sectional study. Methods: setting: Cornea service at Mayo Clinic, Rochester, Minnesota. study population: Sixty-one eyes with clear grafts at 14.6 ± 10.5 years after PK; 12 eyes with late endothelial failure (LEF) at 19.7 ± 6.4 years after PK; 41 normal eyes. observation procedures: PK. main outcome measures: Backscatter from different depths of the cornea was measured by a custom scatterometer; intraocular forward light scatter was measured with a stray light meter; high-contrast visual acuity (HCVA) was measured by Early Treatment Diabetic Retinopathy Study (ETDRS) or Snellen chart; mesopic and photopic low-contrast visual acuity (LCVA) were measured with a 10% contrast chart. Results: Backscatter from the anterior, middle (stroma), and posterior thirds of the cornea was higher in clear grafts compared with normal (P < .001), and higher in grafts with LEF compared with clear grafts (P < .001). Corneal stromal backscatter from clear grafts correlated with time after keratoplasty (r = 0.21; P = .006; n = 61). Forward light scatter was higher in eyes with clear grafts compared with normal (P ≤ .006), and higher in eyes with LEF compared with clear grafts (P ≤ .01). Corneal stromal backscatter from clear grafts correlated with HCVA (r = 0.34; P = .02; n = 52), mesopic LCVA (r = 0.36; P = .01; n = 28), and photopic LCVA (r = 0.57; P < .001; n = 28). Forward scatter in eyes with clear grafts correlated with photopic LCVA (r = 0.38; P = .04; n = 26). Conclusions: Light scattered from the cornea increases with time after PK and is associated with decreased high- and low-contrast vision.
UR - http://www.scopus.com/inward/record.url?scp=56249147769&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56249147769&partnerID=8YFLogxK
U2 - 10.1016/j.ajo.2008.07.018
DO - 10.1016/j.ajo.2008.07.018
M3 - Article
C2 - 18774549
AN - SCOPUS:56249147769
SN - 0002-9394
VL - 146
SP - 913
EP - 919
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 6
ER -