The effect of carbon dioxide on the diameter of brain capillaries

John L.D. Atkinson, Robert E. Anderson, Thoralf M. Sundt

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Cerebral capillaries in cats subjected to variations in carbon dioxide tensions were studied using carbon black perfusion fixation. Five animals each were grouped into hypocapnia, normocapnia, and hypercapnia and 500 cortical, 250 white matter and 250 caudate nucleus capillaries per group were analyzed at 400 × magnification. Capillary diameters were found to change significantly in the cortex (6.1-10.0 μm), white matter (6.5-9.6 μm) and caudate nucleus (6.3-8.8 μm) from hypocapnia to hypercapnia, respectively. These findings suggest that capillary vasomotion occurs and that capillaries are not rigid tubes as previously portrayed.

Original languageEnglish (US)
Pages (from-to)333-340
Number of pages8
JournalBrain Research
Volume517
Issue number1-2
DOIs
StatePublished - May 28 1990

Keywords

  • Capillary recruitment
  • Capillary vasomotion
  • Carbon black
  • Microcirculation
  • Perfusion fixation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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  • Cite this

    Atkinson, J. L. D., Anderson, R. E., & Sundt, T. M. (1990). The effect of carbon dioxide on the diameter of brain capillaries. Brain Research, 517(1-2), 333-340. https://doi.org/10.1016/0006-8993(90)91046-J