The effect of carbon dioxide on the diameter of brain capillaries

John L.D. Atkinson; Robert E. Anderson; Thoralf M. Sundt

doi:10.1016/0006-8993(90)91046-J

The effect of carbon dioxide on the diameter of brain capillaries

John L.D. Atkinson, Robert E. Anderson, Thoralf M. Sundt

Neurosurgery

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

Cerebral capillaries in cats subjected to variations in carbon dioxide tensions were studied using carbon black perfusion fixation. Five animals each were grouped into hypocapnia, normocapnia, and hypercapnia and 500 cortical, 250 white matter and 250 caudate nucleus capillaries per group were analyzed at 400 × magnification. Capillary diameters were found to change significantly in the cortex (6.1-10.0 μm), white matter (6.5-9.6 μm) and caudate nucleus (6.3-8.8 μm) from hypocapnia to hypercapnia, respectively. These findings suggest that capillary vasomotion occurs and that capillaries are not rigid tubes as previously portrayed.

Original language	English (US)
Pages (from-to)	333-340
Number of pages	8
Journal	Brain Research
Volume	517
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(90)91046-J
State	Published - May 28 1990

Keywords

Capillary recruitment
Capillary vasomotion
Carbon black
Microcirculation
Perfusion fixation

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "The effect of carbon dioxide on the diameter of brain capillaries",

abstract = "Cerebral capillaries in cats subjected to variations in carbon dioxide tensions were studied using carbon black perfusion fixation. Five animals each were grouped into hypocapnia, normocapnia, and hypercapnia and 500 cortical, 250 white matter and 250 caudate nucleus capillaries per group were analyzed at 400 × magnification. Capillary diameters were found to change significantly in the cortex (6.1-10.0 μm), white matter (6.5-9.6 μm) and caudate nucleus (6.3-8.8 μm) from hypocapnia to hypercapnia, respectively. These findings suggest that capillary vasomotion occurs and that capillaries are not rigid tubes as previously portrayed.",

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AU - Atkinson, John L.D.

AU - Anderson, Robert E.

AU - Sundt, Thoralf M.

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N2 - Cerebral capillaries in cats subjected to variations in carbon dioxide tensions were studied using carbon black perfusion fixation. Five animals each were grouped into hypocapnia, normocapnia, and hypercapnia and 500 cortical, 250 white matter and 250 caudate nucleus capillaries per group were analyzed at 400 × magnification. Capillary diameters were found to change significantly in the cortex (6.1-10.0 μm), white matter (6.5-9.6 μm) and caudate nucleus (6.3-8.8 μm) from hypocapnia to hypercapnia, respectively. These findings suggest that capillary vasomotion occurs and that capillaries are not rigid tubes as previously portrayed.

AB - Cerebral capillaries in cats subjected to variations in carbon dioxide tensions were studied using carbon black perfusion fixation. Five animals each were grouped into hypocapnia, normocapnia, and hypercapnia and 500 cortical, 250 white matter and 250 caudate nucleus capillaries per group were analyzed at 400 × magnification. Capillary diameters were found to change significantly in the cortex (6.1-10.0 μm), white matter (6.5-9.6 μm) and caudate nucleus (6.3-8.8 μm) from hypocapnia to hypercapnia, respectively. These findings suggest that capillary vasomotion occurs and that capillaries are not rigid tubes as previously portrayed.

KW - Capillary recruitment

KW - Capillary vasomotion

KW - Carbon black

KW - Microcirculation

KW - Perfusion fixation

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The effect of carbon dioxide on the diameter of brain capillaries

Abstract

Keywords

ASJC Scopus subject areas

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