The effect of aging on endoneurial blood flow, hyperemic response and oxygen-free radicals in rat sciatic nerve

Mikihiro Kihara; Kim K. Nickander; Phillip A. Low

doi:10.1016/0006-8993(91)91178-4

The effect of aging on endoneurial blood flow, hyperemic response and oxygen-free radicals in rat sciatic nerve

Mikihiro Kihara, Kim K. Nickander, Phillip A. Low

Neurology

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Electrophysiologic abnormalities and reduced energy metabolic rate develop in aging nerves. We investigated the effects of aging on nerve blood flow (NBF) in Fischer rats aged 2, 12, 24 and 30 months. NBF regressed negatively with increasing age and this decline was associated with an increase in nerve vascular resistance. Twenty minutes of nerve stimulation resulted in an increase in blood flow by about 50% in adult animals and did not decline with increasing age. As indices of oxygen free radical activity, we measured conjugated dienes, hydroperoxides, and norepinephrine from 2 to 30 months. There was a gradual decline with increasing age of all indices. We conclude that NBF declines with aging due to reduced microvascular caliber. These vessels retain their hyperemic response and oxygen free radical activity is less with increasing age.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Brain Research
Volume	562
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(91)91178-4
State	Published - Oct 18 1991

Keywords

Aging
Endoneurial blood flow
Oxygen free radical

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(91)91178-4

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abstract = "Electrophysiologic abnormalities and reduced energy metabolic rate develop in aging nerves. We investigated the effects of aging on nerve blood flow (NBF) in Fischer rats aged 2, 12, 24 and 30 months. NBF regressed negatively with increasing age and this decline was associated with an increase in nerve vascular resistance. Twenty minutes of nerve stimulation resulted in an increase in blood flow by about 50% in adult animals and did not decline with increasing age. As indices of oxygen free radical activity, we measured conjugated dienes, hydroperoxides, and norepinephrine from 2 to 30 months. There was a gradual decline with increasing age of all indices. We conclude that NBF declines with aging due to reduced microvascular caliber. These vessels retain their hyperemic response and oxygen free radical activity is less with increasing age.",

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AB - Electrophysiologic abnormalities and reduced energy metabolic rate develop in aging nerves. We investigated the effects of aging on nerve blood flow (NBF) in Fischer rats aged 2, 12, 24 and 30 months. NBF regressed negatively with increasing age and this decline was associated with an increase in nerve vascular resistance. Twenty minutes of nerve stimulation resulted in an increase in blood flow by about 50% in adult animals and did not decline with increasing age. As indices of oxygen free radical activity, we measured conjugated dienes, hydroperoxides, and norepinephrine from 2 to 30 months. There was a gradual decline with increasing age of all indices. We conclude that NBF declines with aging due to reduced microvascular caliber. These vessels retain their hyperemic response and oxygen free radical activity is less with increasing age.

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The effect of aging on endoneurial blood flow, hyperemic response and oxygen-free radicals in rat sciatic nerve

Abstract

Keywords

ASJC Scopus subject areas

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