The effect of aging on endoneurial blood flow, hyperemic response and oxygen-free radicals in rat sciatic nerve

Mikihiro Kihara, Kim K. Nickander, Phillip A. Low

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Electrophysiologic abnormalities and reduced energy metabolic rate develop in aging nerves. We investigated the effects of aging on nerve blood flow (NBF) in Fischer rats aged 2, 12, 24 and 30 months. NBF regressed negatively with increasing age and this decline was associated with an increase in nerve vascular resistance. Twenty minutes of nerve stimulation resulted in an increase in blood flow by about 50% in adult animals and did not decline with increasing age. As indices of oxygen free radical activity, we measured conjugated dienes, hydroperoxides, and norepinephrine from 2 to 30 months. There was a gradual decline with increasing age of all indices. We conclude that NBF declines with aging due to reduced microvascular caliber. These vessels retain their hyperemic response and oxygen free radical activity is less with increasing age.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalBrain Research
Volume562
Issue number1
DOIs
StatePublished - Oct 18 1991

Keywords

  • Aging
  • Endoneurial blood flow
  • Oxygen free radical

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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