The diagnostic value of splenectomy in patients without a definitive preoperative diagnosis

Patrick T. Hangge, William W. Sheaffer, Matthew Neville, Nabil Wasif, Richard J. Gray, Barbara A Pockaj, Chee Chee H. Stucky

Research output: Contribution to journalArticle

Abstract

Background: The purpose of this study was to describe the diagnostic value and therapeutic benefit of diagnostic splenectomy. Methods: Retrospective review was performed of patients undergoing splenectomy with an unknown diagnosis (UD), a hematologic malignancy (HM) or idiopathic thrombocytopenic purpura. Surgical indications and postoperative outcomes were evaluated. Results: 113 splenectomy patients were identified. Of the UD patients undergoing splenectomy, 46% (n = 16) received a definitive diagnosis postoperatively. A change in diagnosis occurred in 12% (n = 4) of HM patients. Complete symptom relief was observed more often in UD patients who received a definitive diagnosis after splenectomy 69% (n = 11), compared to the 47% (n = 9) who did not receive definitive diagnosis postoperatively. Conclusions: The diagnostic ability of splenectomy was 46% when the diagnosis was unknown preoperatively. Additionally, a majority of patients experienced relief of symptoms postoperatively. Splenectomy may be a useful diagnostic and therapeutic tool in select UD and HM patients.

Original languageEnglish (US)
JournalAmerican Journal of Surgery
DOIs
StateAccepted/In press - Jan 1 2018

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Splenectomy
Hematologic Neoplasms
Idiopathic Thrombocytopenic Purpura
Therapeutics

Keywords

  • Diagnostic
  • Hematologic malignancy
  • Splenectomy

ASJC Scopus subject areas

  • Surgery

Cite this

The diagnostic value of splenectomy in patients without a definitive preoperative diagnosis. / Hangge, Patrick T.; Sheaffer, William W.; Neville, Matthew; Wasif, Nabil; Gray, Richard J.; Pockaj, Barbara A; Stucky, Chee Chee H.

In: American Journal of Surgery, 01.01.2018.

Research output: Contribution to journalArticle

Hangge, Patrick T. ; Sheaffer, William W. ; Neville, Matthew ; Wasif, Nabil ; Gray, Richard J. ; Pockaj, Barbara A ; Stucky, Chee Chee H. / The diagnostic value of splenectomy in patients without a definitive preoperative diagnosis. In: American Journal of Surgery. 2018.
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