The death receptor TRAIL in cancer cell apoptosis

Norihisa Ishimura; Gregory J. Gores

doi:10.4993/acrt.13.1

The death receptor TRAIL in cancer cell apoptosis

Norihisa Ishimura, Gregory J. Gores

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

Abstract

Apoptosis is a key regulator or tissue homeostasis. Death ligands and death receptors of the tumor necrosis factor (TNF) family play crucial roles in mediating apoptosis. TNF-related apoptosis-inducing ligand (TRAIL) is unique amongst death ligands in that it uniquely induces apoptosis in transformed cells, but not normal cells. Indeed, TRAIL is being developed as an anticancer therapy. However, many malignant tumors are resistant to apoptosis induction by TRAIL. Understanding the mechanism of resistance to TRAIL-mediated apoptosis will not only provide insight regarding transduction of the death signal, but will also be essential for designing strategies to overcome resistance to TRAIL for clinical applicatons. In this review, we focus on the apoptosis signaling pathways stimulated by TRAIL, and summarize recent clues regarding TRAIL physiology.

Original language	English (US)
Pages (from-to)	1-10
Number of pages	10
Journal	Annals of Cancer Research and Therapy
Volume	13
Issue number	1-2
DOIs	https://doi.org/10.4993/acrt.13.1
State	Published - 2005

Keywords

Apoptosis
Cancer
Death receptor
Fas
TNF-α
TRAIL

ASJC Scopus subject areas

Oncology
Cancer Research
Pharmacology (medical)

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10.4993/acrt.13.1

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abstract = "Apoptosis is a key regulator or tissue homeostasis. Death ligands and death receptors of the tumor necrosis factor (TNF) family play crucial roles in mediating apoptosis. TNF-related apoptosis-inducing ligand (TRAIL) is unique amongst death ligands in that it uniquely induces apoptosis in transformed cells, but not normal cells. Indeed, TRAIL is being developed as an anticancer therapy. However, many malignant tumors are resistant to apoptosis induction by TRAIL. Understanding the mechanism of resistance to TRAIL-mediated apoptosis will not only provide insight regarding transduction of the death signal, but will also be essential for designing strategies to overcome resistance to TRAIL for clinical applicatons. In this review, we focus on the apoptosis signaling pathways stimulated by TRAIL, and summarize recent clues regarding TRAIL physiology.",

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AU - Ishimura, Norihisa

AU - Gores, Gregory J.

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AB - Apoptosis is a key regulator or tissue homeostasis. Death ligands and death receptors of the tumor necrosis factor (TNF) family play crucial roles in mediating apoptosis. TNF-related apoptosis-inducing ligand (TRAIL) is unique amongst death ligands in that it uniquely induces apoptosis in transformed cells, but not normal cells. Indeed, TRAIL is being developed as an anticancer therapy. However, many malignant tumors are resistant to apoptosis induction by TRAIL. Understanding the mechanism of resistance to TRAIL-mediated apoptosis will not only provide insight regarding transduction of the death signal, but will also be essential for designing strategies to overcome resistance to TRAIL for clinical applicatons. In this review, we focus on the apoptosis signaling pathways stimulated by TRAIL, and summarize recent clues regarding TRAIL physiology.

KW - Apoptosis

KW - Cancer

KW - Death receptor

KW - Fas

KW - TNF-α

KW - TRAIL

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The death receptor TRAIL in cancer cell apoptosis

Abstract

Keywords

ASJC Scopus subject areas

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