@article{c297870d94944b8aa848f0bc861299d5,
title = "The CREST-2 experience with the evolving challenges of COVID-19: A clinical trial in a pandemic",
abstract = "The coronavirus disease 2019 pandemic has disrupted the lives of whole communities and nations. The multinational multicenter National Institute of Neurological Disorders and Stroke Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial stroke prevention trial rapidly experienced the effects of the pandemic and had to temporarily suspend new enrollments and shift patient follow-up activities from in-person clinic visits to telephone contacts. There is an ethical obligation to the patients to protect their health while taking every feasible step to ensure that the goals of the trial are successfully met. Here, we describe the effects of the pandemic on the trial and steps that are being taken to mitigate the effects of the pandemic so that trial objectives can be met.",
author = "Meschia, {James F.} and Barrett, {Kevin M.} and Brown, {Robert D.} and Turan, {Tanya N.} and Howard, {Virginia J.} and Voeks, {Jenifer H.} and Lal, {Brajesh K.} and George Howard and Brott, {Thomas G.}",
note = "Funding Information: The CREST-2 trials are supported by cooperative agreements U01 NS080168 and U01 NS080165 from the National Institute of Neurological Disorders and Stroke, NIH, and by the Centers for Medicare and Medicaid Services (CMS), Department of Health and Human Services. Additional support for CREST-2 comes from StrokeNet U01 NS086872. The authors thank the other investigators, the staff, and the participants of the CREST-2 trials for their valuable contributions. A full list of participating CREST-2 investigators and institutions can be found at crest2trial.org. The authors thank Ms. Kassondra Guzman and Mrs. Sothear Luke for technical assistance with the online surveys and Mrs. Colleen McLeod for assistance with the process of submitting the manuscript. Funding Information: CREST-2 is funded by grants from the National Institute of Neurological Disorders and Stroke (U01NS080168 and U01NS080165). Publisher Copyright: {\textcopyright} 2020 American Academy of Neurology.",
year = "2020",
month = jul,
day = "7",
doi = "10.1212/WNL.0000000000009698",
language = "English (US)",
volume = "95",
pages = "29--36",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "1",
}