The clinical relevance of antidepressant interaction with neurotransmitter transporters and receptors

Elliott Richelson

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

This review presents the pharmacology of antidepressants as it relates to their effects on several neurotransmitters and their receptors. A theory about the mechanism of action of these drugs is presented, along with data for their affinities at human transporters for norepinephrine, serotonin, and dopamine, and at several different neurotransmitter receptors. This blockade by antidepressants of transporters and receptors is thought to relate to therapeutic and adverse effects of these compounds. Knowledge of this preclinical pharmacology of antidepressants will help the clinician understand the basis of certain adverse effects and drug interactions that can be avoided or minimized.

Original languageEnglish (US)
Pages (from-to)133-150
Number of pages18
JournalPsychopharmacology Bulletin
Volume36
Issue number4
StatePublished - Sep 1 2002

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Neurotransmitter Transport Proteins
Neurotransmitter Receptor
Antidepressive Agents
Pharmacology
Norepinephrine Plasma Membrane Transport Proteins
Serotonin Plasma Membrane Transport Proteins
Dopamine Plasma Membrane Transport Proteins
Therapeutic Uses
Drug Interactions
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

The clinical relevance of antidepressant interaction with neurotransmitter transporters and receptors. / Richelson, Elliott.

In: Psychopharmacology Bulletin, Vol. 36, No. 4, 01.09.2002, p. 133-150.

Research output: Contribution to journalReview article

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