The changing epidemiology of hepatitis C virus infection in the United States: National health and nutrition examination survey 2001 through 2010

Ivo Ditah, Fausta Ditah, Pardha Devaki, Oforbuike Ewelukwa, Chobufo Ditah, Basile Njei, Henry N. Luma, Michael Charlton

Research output: Contribution to journalArticle

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Abstract

Background & Aims In light of the dramatically changing hepatitis C therapeutic landscape, knowledge of the current burden of HCV infection in the general population of the United States is critical. Methods The National Health and Nutrition Examination survey collects nationally representative data on HCV infection in the civilian population of the United States. Data from 2001 to 2010 were combined for this study. HCV testing was completed in 38,025 participants. Results The prevalence of anti-HCV in the United Sates decreased from 1.9% (95% CI 1.5%-2.5%) in 2001-2002 to 1.3% (95% CI 0.9%-1.8%) in 2005-2006, and remained stable up to 2010. About 67% of all infected persons were positive for HCV RNA, indicating 2.3 million people with chronic HCV infection, of whom 68% have genotype 1. Seventy percent of infected persons were born between 1945 and 1965, with prevalence of 3.5% (95% CI 2.2%-4.8%). The stable rate since 2006 is mostly related to prevalent cases and foreign born persons migrating into US. Other important risk factors include less education and low economic status. Race, HIV status, number of sexual partners, and blood transfusions are no longer associated with HCV infection. Conclusions As of 2010, approximately 2.3 million persons were chronically infected with Hepatitis C in the US. Most of those infected are prevalent, rather than incident cases. The prevalence of HCV was on the decline, but has stabilized since 2006. Future studies should explore reasons for no decline in HCV prevalence since 2006.

Original languageEnglish (US)
Pages (from-to)691-698
Number of pages8
JournalJournal of Hepatology
Volume60
Issue number4
DOIs
StatePublished - 2014

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Nutrition Surveys
Virus Diseases
Hepacivirus
Epidemiology
Hepatitis C
Infection
Sexual Partners
Blood Transfusion
Population
Genotype
Economics
HIV
RNA
Education
Therapeutics

Keywords

  • Hepatitis C infection
  • NHANES
  • Prevalence
  • Risk factors
  • Trends

ASJC Scopus subject areas

  • Hepatology

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The changing epidemiology of hepatitis C virus infection in the United States : National health and nutrition examination survey 2001 through 2010. / Ditah, Ivo; Ditah, Fausta; Devaki, Pardha; Ewelukwa, Oforbuike; Ditah, Chobufo; Njei, Basile; Luma, Henry N.; Charlton, Michael.

In: Journal of Hepatology, Vol. 60, No. 4, 2014, p. 691-698.

Research output: Contribution to journalArticle

Ditah, Ivo ; Ditah, Fausta ; Devaki, Pardha ; Ewelukwa, Oforbuike ; Ditah, Chobufo ; Njei, Basile ; Luma, Henry N. ; Charlton, Michael. / The changing epidemiology of hepatitis C virus infection in the United States : National health and nutrition examination survey 2001 through 2010. In: Journal of Hepatology. 2014 ; Vol. 60, No. 4. pp. 691-698.
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abstract = "Background & Aims In light of the dramatically changing hepatitis C therapeutic landscape, knowledge of the current burden of HCV infection in the general population of the United States is critical. Methods The National Health and Nutrition Examination survey collects nationally representative data on HCV infection in the civilian population of the United States. Data from 2001 to 2010 were combined for this study. HCV testing was completed in 38,025 participants. Results The prevalence of anti-HCV in the United Sates decreased from 1.9{\%} (95{\%} CI 1.5{\%}-2.5{\%}) in 2001-2002 to 1.3{\%} (95{\%} CI 0.9{\%}-1.8{\%}) in 2005-2006, and remained stable up to 2010. About 67{\%} of all infected persons were positive for HCV RNA, indicating 2.3 million people with chronic HCV infection, of whom 68{\%} have genotype 1. Seventy percent of infected persons were born between 1945 and 1965, with prevalence of 3.5{\%} (95{\%} CI 2.2{\%}-4.8{\%}). The stable rate since 2006 is mostly related to prevalent cases and foreign born persons migrating into US. Other important risk factors include less education and low economic status. Race, HIV status, number of sexual partners, and blood transfusions are no longer associated with HCV infection. Conclusions As of 2010, approximately 2.3 million persons were chronically infected with Hepatitis C in the US. Most of those infected are prevalent, rather than incident cases. The prevalence of HCV was on the decline, but has stabilized since 2006. Future studies should explore reasons for no decline in HCV prevalence since 2006.",
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