TY - JOUR
T1 - The cerebellar channelopathy of multiple sclerosis
AU - Waxman, Stephen G.
AU - Kantarci, Orhun
N1 - Publisher Copyright:
© 2016 American Academy of Neurology.
PY - 2016/2/2
Y1 - 2016/2/2
N2 - Clinical abnormalities in multiple sclerosis (MS) have traditionally been attributed to inflammation, demyelination, or degeneration of axons within the brain and spinal cord. Among those symptoms, clinical deficits due to cerebellar dysfunction, including loss of coordination, ataxia, tremor, and dysarthria, can reduce function substantially, are less likely to remit, and are more likely to be associated with progressive MS in the future.1 Interestingly, cerebellar signs and symptoms are sometimes seen in patients in whom structural lesions or inflammation of the cerebellum cannot be detected. These symptoms can be paroxysmal, similar to trigeminal neuralgia in patients with MS, which preferentially responds to sodium channel blockers.
AB - Clinical abnormalities in multiple sclerosis (MS) have traditionally been attributed to inflammation, demyelination, or degeneration of axons within the brain and spinal cord. Among those symptoms, clinical deficits due to cerebellar dysfunction, including loss of coordination, ataxia, tremor, and dysarthria, can reduce function substantially, are less likely to remit, and are more likely to be associated with progressive MS in the future.1 Interestingly, cerebellar signs and symptoms are sometimes seen in patients in whom structural lesions or inflammation of the cerebellum cannot be detected. These symptoms can be paroxysmal, similar to trigeminal neuralgia in patients with MS, which preferentially responds to sodium channel blockers.
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U2 - 10.1212/WNL.0000000000002338
DO - 10.1212/WNL.0000000000002338
M3 - Review article
C2 - 26740676
AN - SCOPUS:84957603169
SN - 0028-3878
VL - 86
SP - 406
EP - 407
JO - Neurology
JF - Neurology
IS - 5
ER -