The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions

Ninghai Wang, Abhay Satoskar, William Alvis Faubion, Duncan Howie, Susumu Okamoto, Stefan Feske, Charles Gullo, Kareem Clarke, Miriam Rodriguez Sosa, Arlene H. Sharpe, Cox Terhorst

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Signaling lymphocyte activation molecule (SLAM), a glycoprotein expressed on activated lymphocytes and antigen-presenting cells, has been shown to be a coregulator of antigen-driven T cell responses and is one of the two receptors for measles virus. Here we show that T cell receptor-induced interleukin (IL)-4 secretion by SLAM-/- CD4+ cells is down-regulated, whereas interferon γ production by CD4+ T cells is only slightly up-regulated. Although SLAM controls production of IL-12, tumor necrosis factor, and nitric oxide in response to lipopolysaccharide (LPS) by macrophages, SLAM does not regulate phagocytosis and responses to peptidoglycan or CpG. Thus, SLAM acts as a coreceptor that regulates signals transduced by the major LPS receptor Toll-like receptor 4 on the surface of mouse macrophages. A defective macrophage function resulted in an inability of SLAM-/- C57B1/6 mice to remove the parasite Leishmania major. We conclude that the coreceptor SLAM plays a central role at the interface of acquired and innate immune responses.

Original languageEnglish (US)
Pages (from-to)1255-1264
Number of pages10
JournalJournal of Experimental Medicine
Volume199
Issue number9
DOIs
StatePublished - May 3 2004
Externally publishedYes

Fingerprint

Cell Surface Receptors
Lymphocyte Activation
Macrophages
T-Lymphocytes
CD14 Antigens
Leishmania major
CD4 Antigens
Measles virus
Toll-Like Receptor 4
Peptidoglycan
Antigen-Presenting Cells
Interleukin-12
T-Cell Antigen Receptor
Phagocytosis
Innate Immunity
Interleukin-4
Interferons
Lipopolysaccharides
Glycoproteins
Nitric Oxide

Keywords

  • L. major
  • Macrophage
  • SLAM
  • T cell

ASJC Scopus subject areas

  • Immunology

Cite this

Wang, N., Satoskar, A., Faubion, W. A., Howie, D., Okamoto, S., Feske, S., ... Terhorst, C. (2004). The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions. Journal of Experimental Medicine, 199(9), 1255-1264. https://doi.org/10.1084/jem.20031835

The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions. / Wang, Ninghai; Satoskar, Abhay; Faubion, William Alvis; Howie, Duncan; Okamoto, Susumu; Feske, Stefan; Gullo, Charles; Clarke, Kareem; Sosa, Miriam Rodriguez; Sharpe, Arlene H.; Terhorst, Cox.

In: Journal of Experimental Medicine, Vol. 199, No. 9, 03.05.2004, p. 1255-1264.

Research output: Contribution to journalArticle

Wang, N, Satoskar, A, Faubion, WA, Howie, D, Okamoto, S, Feske, S, Gullo, C, Clarke, K, Sosa, MR, Sharpe, AH & Terhorst, C 2004, 'The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions', Journal of Experimental Medicine, vol. 199, no. 9, pp. 1255-1264. https://doi.org/10.1084/jem.20031835
Wang, Ninghai ; Satoskar, Abhay ; Faubion, William Alvis ; Howie, Duncan ; Okamoto, Susumu ; Feske, Stefan ; Gullo, Charles ; Clarke, Kareem ; Sosa, Miriam Rodriguez ; Sharpe, Arlene H. ; Terhorst, Cox. / The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions. In: Journal of Experimental Medicine. 2004 ; Vol. 199, No. 9. pp. 1255-1264.
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