The broad and challenging landscape of extranodal lymphoproliferations

Snjezana Dotlic, Maurilio Ponzoni, Rebecca L. King, Ilske Oschlies, Judith Ferry, Maria Calaminici, Santiago Montes-Moreno, John R. Goodlad, German Ott, Alexandra Traverse-Glehen

Research output: Contribution to journalArticle

Abstract

Two sessions in the workshop of the 19th meeting of the European Association for Haematopathology termed “challenging extranodal lymphoproliferations” and “extranodal non-site-specific lymphoproliferations”, dealt with a series of heterogenous cases. These included lymphoproliferations of all cell lineages, from reactive lesions mimicking lymphomas through indolent lymphoid neoplasia and tumours with unclear biological behaviour to aggressive and transformed lymphomas. The themes addressed included cases with borderline features between hyperplastic and neoplastic lesions, the diagnostic spectrum of IgG4-related disease, T cell lymphoproliferations arising in extranodal sites with presumed indolent behaviour, diverse clinical presentations of intravascular large B cell lymphoma, diagnostic problems encountered with tumours displaying plasmablastic morphology, pitfalls concerning rare entities like adult T cell lymphoma/leukaemia (ATLL) and extranodal natural killer/T cell (NK/T) lymphomas, and unusual clinical presentations of various lymphomas. Altogether, within the frame of these two sessions, 75 cases remarkably differing in their clinical background, genetic features and overall need for a meticulous diagnostic approach were presented and discussed. In this paper, the salient points raised during the discussion of the cases, current diagnostic concepts and recommendations relevant to the diagnosis of these lymphoproliferations are described.

Original languageEnglish (US)
JournalVirchows Archiv
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Lymphoma
Adult T Cell Leukemia Lymphoma
Neoplasms
Natural Killer T-Cells
T-Cell Lymphoma
B-Cell Lymphoma
Cell Lineage
Immunoglobulin G
T-Lymphocytes
Education
Genetic Background

Keywords

  • Adult T cell lymphoma/leukaemia
  • Extranodal Hodgkin lymphoma
  • Extranodal NK/T cell lymphoma
  • High grade B cell lymphoma
  • IgG4-related disease
  • Indolent lymphoproliferations
  • Intravascular large B cell lymphoma
  • Plasmablastic lymphoma
  • Plasmablastic myeloma
  • Transformed and composite lymphomas

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Dotlic, S., Ponzoni, M., King, R. L., Oschlies, I., Ferry, J., Calaminici, M., ... Traverse-Glehen, A. (Accepted/In press). The broad and challenging landscape of extranodal lymphoproliferations. Virchows Archiv. https://doi.org/10.1007/s00428-019-02702-w

The broad and challenging landscape of extranodal lymphoproliferations. / Dotlic, Snjezana; Ponzoni, Maurilio; King, Rebecca L.; Oschlies, Ilske; Ferry, Judith; Calaminici, Maria; Montes-Moreno, Santiago; Goodlad, John R.; Ott, German; Traverse-Glehen, Alexandra.

In: Virchows Archiv, 01.01.2019.

Research output: Contribution to journalArticle

Dotlic, S, Ponzoni, M, King, RL, Oschlies, I, Ferry, J, Calaminici, M, Montes-Moreno, S, Goodlad, JR, Ott, G & Traverse-Glehen, A 2019, 'The broad and challenging landscape of extranodal lymphoproliferations', Virchows Archiv. https://doi.org/10.1007/s00428-019-02702-w
Dotlic, Snjezana ; Ponzoni, Maurilio ; King, Rebecca L. ; Oschlies, Ilske ; Ferry, Judith ; Calaminici, Maria ; Montes-Moreno, Santiago ; Goodlad, John R. ; Ott, German ; Traverse-Glehen, Alexandra. / The broad and challenging landscape of extranodal lymphoproliferations. In: Virchows Archiv. 2019.
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