The blue man: A novel cutaneous manifestation of systemic amyloidosis

Mark Campbell, Allison Rosenthal, Madappa Kundranda, Amanda Pickert, David Dicaudo, Ahmet Dogan, Joseph Mikhael

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Multiple cutaneous manifestations of amyloidosis have been described, and include periorbital purpura, plaques, nodules, and papules. Blue skin tint is not a previously described feature of cutaneous amyloidosis. We report the clinical case of a patient with known multiple myeloma and amyloidosis of the gastrointestinal tract who presented with progressive "blueness" of the skin. Dermatopathological examination and mass spectrometry of a skin biopsy specimen revealed the presence of subcutaneous amyloid light chain (AL) deposition. We believe this to be the first reported case of blue skin resulting from systemic amyloidosis.

Original languageEnglish (US)
Pages (from-to)156-159
Number of pages4
Issue number3
StatePublished - Sep 2011


  • Blue skin discoloration
  • Cutaneous amyloidosis
  • Organ-limited cutaneous amyloidosis

ASJC Scopus subject areas

  • Internal Medicine


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