TY - JOUR
T1 - The blue man
T2 - A novel cutaneous manifestation of systemic amyloidosis
AU - Campbell, Mark
AU - Rosenthal, Allison
AU - Kundranda, Madappa
AU - Pickert, Amanda
AU - Dicaudo, David
AU - Dogan, Ahmet
AU - Mikhael, Joseph
PY - 2011/9/1
Y1 - 2011/9/1
N2 - Multiple cutaneous manifestations of amyloidosis have been described, and include periorbital purpura, plaques, nodules, and papules. Blue skin tint is not a previously described feature of cutaneous amyloidosis. We report the clinical case of a patient with known multiple myeloma and amyloidosis of the gastrointestinal tract who presented with progressive "blueness" of the skin. Dermatopathological examination and mass spectrometry of a skin biopsy specimen revealed the presence of subcutaneous amyloid light chain (AL) deposition. We believe this to be the first reported case of blue skin resulting from systemic amyloidosis.
AB - Multiple cutaneous manifestations of amyloidosis have been described, and include periorbital purpura, plaques, nodules, and papules. Blue skin tint is not a previously described feature of cutaneous amyloidosis. We report the clinical case of a patient with known multiple myeloma and amyloidosis of the gastrointestinal tract who presented with progressive "blueness" of the skin. Dermatopathological examination and mass spectrometry of a skin biopsy specimen revealed the presence of subcutaneous amyloid light chain (AL) deposition. We believe this to be the first reported case of blue skin resulting from systemic amyloidosis.
KW - Blue skin discoloration
KW - Cutaneous amyloidosis
KW - Organ-limited cutaneous amyloidosis
UR - http://www.scopus.com/inward/record.url?scp=80052250764&partnerID=8YFLogxK
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U2 - 10.3109/13506129.2011.571318
DO - 10.3109/13506129.2011.571318
M3 - Article
C2 - 21506660
AN - SCOPUS:80052250764
VL - 18
SP - 156
EP - 159
JO - Amyloid
JF - Amyloid
SN - 1350-6129
IS - 3
ER -