The blue man: A novel cutaneous manifestation of systemic amyloidosis

Mark Campbell; Allison Rosenthal; Madappa Kundranda; Amanda Pickert; David Dicaudo; Ahmet Dogan; Joseph Mikhael

doi:10.3109/13506129.2011.571318

The blue man: A novel cutaneous manifestation of systemic amyloidosis

Mark Campbell, Allison Rosenthal, Madappa Kundranda, Amanda Pickert, David Dicaudo, Ahmet Dogan, Joseph Mikhael

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Multiple cutaneous manifestations of amyloidosis have been described, and include periorbital purpura, plaques, nodules, and papules. Blue skin tint is not a previously described feature of cutaneous amyloidosis. We report the clinical case of a patient with known multiple myeloma and amyloidosis of the gastrointestinal tract who presented with progressive "blueness" of the skin. Dermatopathological examination and mass spectrometry of a skin biopsy specimen revealed the presence of subcutaneous amyloid light chain (AL) deposition. We believe this to be the first reported case of blue skin resulting from systemic amyloidosis.

Original language	English (US)
Pages (from-to)	156-159
Number of pages	4
Journal	Amyloid
Volume	18
Issue number	3
DOIs	https://doi.org/10.3109/13506129.2011.571318
State	Published - Sep 2011

Keywords

Blue skin discoloration
Cutaneous amyloidosis
Organ-limited cutaneous amyloidosis

ASJC Scopus subject areas

Internal Medicine

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10.3109/13506129.2011.571318

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title = "The blue man: A novel cutaneous manifestation of systemic amyloidosis",

abstract = "Multiple cutaneous manifestations of amyloidosis have been described, and include periorbital purpura, plaques, nodules, and papules. Blue skin tint is not a previously described feature of cutaneous amyloidosis. We report the clinical case of a patient with known multiple myeloma and amyloidosis of the gastrointestinal tract who presented with progressive {"}blueness{"} of the skin. Dermatopathological examination and mass spectrometry of a skin biopsy specimen revealed the presence of subcutaneous amyloid light chain (AL) deposition. We believe this to be the first reported case of blue skin resulting from systemic amyloidosis.",

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AU - Campbell, Mark

AU - Rosenthal, Allison

AU - Kundranda, Madappa

AU - Pickert, Amanda

AU - Dicaudo, David

AU - Dogan, Ahmet

AU - Mikhael, Joseph

PY - 2011/9

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N2 - Multiple cutaneous manifestations of amyloidosis have been described, and include periorbital purpura, plaques, nodules, and papules. Blue skin tint is not a previously described feature of cutaneous amyloidosis. We report the clinical case of a patient with known multiple myeloma and amyloidosis of the gastrointestinal tract who presented with progressive "blueness" of the skin. Dermatopathological examination and mass spectrometry of a skin biopsy specimen revealed the presence of subcutaneous amyloid light chain (AL) deposition. We believe this to be the first reported case of blue skin resulting from systemic amyloidosis.

AB - Multiple cutaneous manifestations of amyloidosis have been described, and include periorbital purpura, plaques, nodules, and papules. Blue skin tint is not a previously described feature of cutaneous amyloidosis. We report the clinical case of a patient with known multiple myeloma and amyloidosis of the gastrointestinal tract who presented with progressive "blueness" of the skin. Dermatopathological examination and mass spectrometry of a skin biopsy specimen revealed the presence of subcutaneous amyloid light chain (AL) deposition. We believe this to be the first reported case of blue skin resulting from systemic amyloidosis.

KW - Blue skin discoloration

KW - Cutaneous amyloidosis

KW - Organ-limited cutaneous amyloidosis

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The blue man: A novel cutaneous manifestation of systemic amyloidosis

Abstract

Keywords

ASJC Scopus subject areas

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