The blue man: A novel cutaneous manifestation of systemic amyloidosis

Mark Campbell; Allison Rosenthal; Madappa Kundranda; Amanda Pickert; David Dicaudo; Ahmet Dogan; Joseph Mikhael

doi:10.3109/13506129.2011.571318

The blue man: A novel cutaneous manifestation of systemic amyloidosis

Mark Campbell, Allison Rosenthal, Madappa Kundranda, Amanda Pickert, David Dicaudo, Ahmet Dogan, Joseph Mikhael

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Multiple cutaneous manifestations of amyloidosis have been described, and include periorbital purpura, plaques, nodules, and papules. Blue skin tint is not a previously described feature of cutaneous amyloidosis. We report the clinical case of a patient with known multiple myeloma and amyloidosis of the gastrointestinal tract who presented with progressive "blueness" of the skin. Dermatopathological examination and mass spectrometry of a skin biopsy specimen revealed the presence of subcutaneous amyloid light chain (AL) deposition. We believe this to be the first reported case of blue skin resulting from systemic amyloidosis.

Original language	English (US)
Pages (from-to)	156-159
Number of pages	4
Journal	Amyloid
Volume	18
Issue number	3
DOIs	https://doi.org/10.3109/13506129.2011.571318
State	Published - Sep 2011

Keywords

Blue skin discoloration
Cutaneous amyloidosis
Organ-limited cutaneous amyloidosis

ASJC Scopus subject areas

Internal Medicine

Access to Document

10.3109/13506129.2011.571318

Cite this

@article{0ee3a2155ff84f8db853b060aaa50e5f,

title = "The blue man: A novel cutaneous manifestation of systemic amyloidosis",

abstract = "Multiple cutaneous manifestations of amyloidosis have been described, and include periorbital purpura, plaques, nodules, and papules. Blue skin tint is not a previously described feature of cutaneous amyloidosis. We report the clinical case of a patient with known multiple myeloma and amyloidosis of the gastrointestinal tract who presented with progressive {"}blueness{"} of the skin. Dermatopathological examination and mass spectrometry of a skin biopsy specimen revealed the presence of subcutaneous amyloid light chain (AL) deposition. We believe this to be the first reported case of blue skin resulting from systemic amyloidosis.",

keywords = "Blue skin discoloration, Cutaneous amyloidosis, Organ-limited cutaneous amyloidosis",

author = "Mark Campbell and Allison Rosenthal and Madappa Kundranda and Amanda Pickert and David Dicaudo and Ahmet Dogan and Joseph Mikhael",

year = "2011",

month = sep,

doi = "10.3109/13506129.2011.571318",

language = "English (US)",

volume = "18",

pages = "156--159",

journal = "Amyloid",

issn = "1350-6129",

publisher = "Informa Healthcare",

number = "3",

}

TY - JOUR

T1 - The blue man

T2 - A novel cutaneous manifestation of systemic amyloidosis

AU - Campbell, Mark

AU - Rosenthal, Allison

AU - Kundranda, Madappa

AU - Pickert, Amanda

AU - Dicaudo, David

AU - Dogan, Ahmet

AU - Mikhael, Joseph

PY - 2011/9

Y1 - 2011/9

N2 - Multiple cutaneous manifestations of amyloidosis have been described, and include periorbital purpura, plaques, nodules, and papules. Blue skin tint is not a previously described feature of cutaneous amyloidosis. We report the clinical case of a patient with known multiple myeloma and amyloidosis of the gastrointestinal tract who presented with progressive "blueness" of the skin. Dermatopathological examination and mass spectrometry of a skin biopsy specimen revealed the presence of subcutaneous amyloid light chain (AL) deposition. We believe this to be the first reported case of blue skin resulting from systemic amyloidosis.

AB - Multiple cutaneous manifestations of amyloidosis have been described, and include periorbital purpura, plaques, nodules, and papules. Blue skin tint is not a previously described feature of cutaneous amyloidosis. We report the clinical case of a patient with known multiple myeloma and amyloidosis of the gastrointestinal tract who presented with progressive "blueness" of the skin. Dermatopathological examination and mass spectrometry of a skin biopsy specimen revealed the presence of subcutaneous amyloid light chain (AL) deposition. We believe this to be the first reported case of blue skin resulting from systemic amyloidosis.

KW - Blue skin discoloration

KW - Cutaneous amyloidosis

KW - Organ-limited cutaneous amyloidosis

UR - http://www.scopus.com/inward/record.url?scp=80052250764&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052250764&partnerID=8YFLogxK

U2 - 10.3109/13506129.2011.571318

DO - 10.3109/13506129.2011.571318

M3 - Article

C2 - 21506660

AN - SCOPUS:80052250764

SN - 1350-6129

VL - 18

SP - 156

EP - 159

JO - Amyloid

JF - Amyloid

IS - 3

ER -

The blue man: A novel cutaneous manifestation of systemic amyloidosis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this