The atrial natriuretic peptide genetic ariant rs5068 is associated with a favorable cardiometabolic phenotype in a mediterranean population

Valentina Cannone, Angelo Baldassare Cefalu, Davide Noto, Christopher G. Scott, Kent R Bailey, Giovanni Cavera, Michele Pagano, Michelangelo Sapienza, Maurizio R. Averna, John C Jr. Burnett

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

OBJECTIVE-We hypothesized that the minor allele of the atrial natriuretic peptide (ANP) genetic variant rs5068 is associated with a favorable cardiometabolic phenotype in a general Mediterranean population. RESEARCH DESIGN AND METHODS-We genotyped a random sample of the residents of Ventimiglia di Sicilia, Sicily, for rs5068. RESULTS-Genotype frequencies of rs5068 are AA, 93.5%; AG, 6.4%; and GG, 0.1%. All subsequent analyses are AA versus AG+GG. After adjusting for age and sex, the minor G allele is associated with lower BMI (estimate [SE]: -1.7 kg/m2 [0.8], P = 0.04). In the AG+GG group, males with HDL cholesterol levels <40 mg/dL are less frequent (P = 0.05) and obesity tends to be less prevalent (P = 0.07). Importantly, the G allele is associated with a lower prevalence of metabolic syndrome (P = 0.02). After adjusting for BMI, the above associations were attenuated. Independently of age, sex, and BMI, the minor allele is also associated with lower systolic blood pressure (-6.0 mmHg [2.5], P = 0.02) and lower prevalence of hypertension (odds ratio 0.41 [95% CI 0.20-0.83], P = 0.01). CONCLUSIONS-The association between the minor allele of rs5068 and a favorable cardiometabolic phenotype that we previously reported in a U.S. population is now replicated in a Mediterranean population in which the G allele of rs5068 is associated with lower blood pressure, BMI, and prevalence of hypertension andmetabolic syndrome. These findings may lead to a diagnostic strategy to assess cardiometabolic risk and lay the foundation for the future development of an ANP or ANP-like therapy for metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)2850-2856
Number of pages7
JournalDiabetes Care
Volume36
Issue number9
DOIs
StatePublished - Sep 2013

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Atrial Natriuretic Factor
Alleles
Phenotype
Population
Blood Pressure
Sicily
Hypertension
HDL Cholesterol
Research Design
Obesity
Odds Ratio
Genotype

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

The atrial natriuretic peptide genetic ariant rs5068 is associated with a favorable cardiometabolic phenotype in a mediterranean population. / Cannone, Valentina; Cefalu, Angelo Baldassare; Noto, Davide; Scott, Christopher G.; Bailey, Kent R; Cavera, Giovanni; Pagano, Michele; Sapienza, Michelangelo; Averna, Maurizio R.; Burnett, John C Jr.

In: Diabetes Care, Vol. 36, No. 9, 09.2013, p. 2850-2856.

Research output: Contribution to journalArticle

Cannone, Valentina ; Cefalu, Angelo Baldassare ; Noto, Davide ; Scott, Christopher G. ; Bailey, Kent R ; Cavera, Giovanni ; Pagano, Michele ; Sapienza, Michelangelo ; Averna, Maurizio R. ; Burnett, John C Jr. / The atrial natriuretic peptide genetic ariant rs5068 is associated with a favorable cardiometabolic phenotype in a mediterranean population. In: Diabetes Care. 2013 ; Vol. 36, No. 9. pp. 2850-2856.
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abstract = "OBJECTIVE-We hypothesized that the minor allele of the atrial natriuretic peptide (ANP) genetic variant rs5068 is associated with a favorable cardiometabolic phenotype in a general Mediterranean population. RESEARCH DESIGN AND METHODS-We genotyped a random sample of the residents of Ventimiglia di Sicilia, Sicily, for rs5068. RESULTS-Genotype frequencies of rs5068 are AA, 93.5{\%}; AG, 6.4{\%}; and GG, 0.1{\%}. All subsequent analyses are AA versus AG+GG. After adjusting for age and sex, the minor G allele is associated with lower BMI (estimate [SE]: -1.7 kg/m2 [0.8], P = 0.04). In the AG+GG group, males with HDL cholesterol levels <40 mg/dL are less frequent (P = 0.05) and obesity tends to be less prevalent (P = 0.07). Importantly, the G allele is associated with a lower prevalence of metabolic syndrome (P = 0.02). After adjusting for BMI, the above associations were attenuated. Independently of age, sex, and BMI, the minor allele is also associated with lower systolic blood pressure (-6.0 mmHg [2.5], P = 0.02) and lower prevalence of hypertension (odds ratio 0.41 [95{\%} CI 0.20-0.83], P = 0.01). CONCLUSIONS-The association between the minor allele of rs5068 and a favorable cardiometabolic phenotype that we previously reported in a U.S. population is now replicated in a Mediterranean population in which the G allele of rs5068 is associated with lower blood pressure, BMI, and prevalence of hypertension andmetabolic syndrome. These findings may lead to a diagnostic strategy to assess cardiometabolic risk and lay the foundation for the future development of an ANP or ANP-like therapy for metabolic syndrome.",
author = "Valentina Cannone and Cefalu, {Angelo Baldassare} and Davide Noto and Scott, {Christopher G.} and Bailey, {Kent R} and Giovanni Cavera and Michele Pagano and Michelangelo Sapienza and Averna, {Maurizio R.} and Burnett, {John C Jr.}",
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T1 - The atrial natriuretic peptide genetic ariant rs5068 is associated with a favorable cardiometabolic phenotype in a mediterranean population

AU - Cannone, Valentina

AU - Cefalu, Angelo Baldassare

AU - Noto, Davide

AU - Scott, Christopher G.

AU - Bailey, Kent R

AU - Cavera, Giovanni

AU - Pagano, Michele

AU - Sapienza, Michelangelo

AU - Averna, Maurizio R.

AU - Burnett, John C Jr.

PY - 2013/9

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N2 - OBJECTIVE-We hypothesized that the minor allele of the atrial natriuretic peptide (ANP) genetic variant rs5068 is associated with a favorable cardiometabolic phenotype in a general Mediterranean population. RESEARCH DESIGN AND METHODS-We genotyped a random sample of the residents of Ventimiglia di Sicilia, Sicily, for rs5068. RESULTS-Genotype frequencies of rs5068 are AA, 93.5%; AG, 6.4%; and GG, 0.1%. All subsequent analyses are AA versus AG+GG. After adjusting for age and sex, the minor G allele is associated with lower BMI (estimate [SE]: -1.7 kg/m2 [0.8], P = 0.04). In the AG+GG group, males with HDL cholesterol levels <40 mg/dL are less frequent (P = 0.05) and obesity tends to be less prevalent (P = 0.07). Importantly, the G allele is associated with a lower prevalence of metabolic syndrome (P = 0.02). After adjusting for BMI, the above associations were attenuated. Independently of age, sex, and BMI, the minor allele is also associated with lower systolic blood pressure (-6.0 mmHg [2.5], P = 0.02) and lower prevalence of hypertension (odds ratio 0.41 [95% CI 0.20-0.83], P = 0.01). CONCLUSIONS-The association between the minor allele of rs5068 and a favorable cardiometabolic phenotype that we previously reported in a U.S. population is now replicated in a Mediterranean population in which the G allele of rs5068 is associated with lower blood pressure, BMI, and prevalence of hypertension andmetabolic syndrome. These findings may lead to a diagnostic strategy to assess cardiometabolic risk and lay the foundation for the future development of an ANP or ANP-like therapy for metabolic syndrome.

AB - OBJECTIVE-We hypothesized that the minor allele of the atrial natriuretic peptide (ANP) genetic variant rs5068 is associated with a favorable cardiometabolic phenotype in a general Mediterranean population. RESEARCH DESIGN AND METHODS-We genotyped a random sample of the residents of Ventimiglia di Sicilia, Sicily, for rs5068. RESULTS-Genotype frequencies of rs5068 are AA, 93.5%; AG, 6.4%; and GG, 0.1%. All subsequent analyses are AA versus AG+GG. After adjusting for age and sex, the minor G allele is associated with lower BMI (estimate [SE]: -1.7 kg/m2 [0.8], P = 0.04). In the AG+GG group, males with HDL cholesterol levels <40 mg/dL are less frequent (P = 0.05) and obesity tends to be less prevalent (P = 0.07). Importantly, the G allele is associated with a lower prevalence of metabolic syndrome (P = 0.02). After adjusting for BMI, the above associations were attenuated. Independently of age, sex, and BMI, the minor allele is also associated with lower systolic blood pressure (-6.0 mmHg [2.5], P = 0.02) and lower prevalence of hypertension (odds ratio 0.41 [95% CI 0.20-0.83], P = 0.01). CONCLUSIONS-The association between the minor allele of rs5068 and a favorable cardiometabolic phenotype that we previously reported in a U.S. population is now replicated in a Mediterranean population in which the G allele of rs5068 is associated with lower blood pressure, BMI, and prevalence of hypertension andmetabolic syndrome. These findings may lead to a diagnostic strategy to assess cardiometabolic risk and lay the foundation for the future development of an ANP or ANP-like therapy for metabolic syndrome.

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