TY - JOUR
T1 - The association of hypertriglyceridemia with cardiovascular events and pancreatitis
T2 - A systematic review and meta-analysis
AU - Murad, M. Hassan
AU - Hazem, Ahmad
AU - Coto-Yglesias, Fernando
AU - Dzyubak, Svitlana
AU - Gupta, Shabnum
AU - Bancos, Irina
AU - Lane, Melanie A.
AU - Erwin, Patricia J.
AU - Berglund, Lars
AU - Elraiyah, Tarig
AU - Montori, Victor M.
N1 - Funding Information:
This review was funded by a contract from the Endocrine Society. The funder had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication. Disclosure statement MM, AH, FC, SD, SG, IB, ML, LB and VM have nothing to declare. Financial support This review was funded by a contract from the Endocrine Society.
PY - 2012/3/31
Y1 - 2012/3/31
N2 - Background: Hypertriglyceridemia may be associated with important complications. The aim of this study is to estimate the magnitude of association and quality of supporting evidence linking hypertriglyceridemia to cardiovascular events and pancreatitis.Methods: We conducted a systematic review of multiple electronic bibliographic databases and subsequent meta-analysis using a random effects model. Studies eligible for this review followed patients longitudinally and evaluated quantitatively the association of fasting hypertriglyceridemia with the outcomes of interest. Reviewers working independently and in duplicate reviewed studies and extracted data.Results: 35 studies provided data sufficient for meta-analysis. The quality of these observational studies was moderate to low with fair level of multivariable adjustments and adequate exposure and outcome ascertainment. Fasting hypertriglyceridemia was significantly associated with cardiovascular death (odds ratios (OR) 1.80; 95% confidence interval (CI) 1.31-2.49), cardiovascular events (OR, 1.37; 95% CI, 1.23-1.53), myocardial infarction (OR, 1.31; 95% CI, 1.15-1.49), and pancreatitis (OR, 3.96; 95% CI, 1.27-12.34, in one study only). The association with all-cause mortality was not statistically significant.Conclusions: The current evidence suggests that fasting hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.Précis: hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.
AB - Background: Hypertriglyceridemia may be associated with important complications. The aim of this study is to estimate the magnitude of association and quality of supporting evidence linking hypertriglyceridemia to cardiovascular events and pancreatitis.Methods: We conducted a systematic review of multiple electronic bibliographic databases and subsequent meta-analysis using a random effects model. Studies eligible for this review followed patients longitudinally and evaluated quantitatively the association of fasting hypertriglyceridemia with the outcomes of interest. Reviewers working independently and in duplicate reviewed studies and extracted data.Results: 35 studies provided data sufficient for meta-analysis. The quality of these observational studies was moderate to low with fair level of multivariable adjustments and adequate exposure and outcome ascertainment. Fasting hypertriglyceridemia was significantly associated with cardiovascular death (odds ratios (OR) 1.80; 95% confidence interval (CI) 1.31-2.49), cardiovascular events (OR, 1.37; 95% CI, 1.23-1.53), myocardial infarction (OR, 1.31; 95% CI, 1.15-1.49), and pancreatitis (OR, 3.96; 95% CI, 1.27-12.34, in one study only). The association with all-cause mortality was not statistically significant.Conclusions: The current evidence suggests that fasting hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.Précis: hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.
KW - Cardiovascular disease
KW - Hypertriglyceridemia
KW - Pancreatitis
KW - Systematic reviews and meta-analysis
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U2 - 10.1186/1472-6823-12-2
DO - 10.1186/1472-6823-12-2
M3 - Article
C2 - 22463676
AN - SCOPUS:84859049036
SN - 1472-6823
VL - 12
JO - BMC Endocrine Disorders
JF - BMC Endocrine Disorders
M1 - 2
ER -