The association of active cancer with venous thromboembolism location: A population-based study

Alfonso J. Tafur, Henna Kalsi, Waldemar E. Wysokinski, Robert D. McBane, Aneel Arjun Ashrani, Randolph Stuart Marks, Daniel J. Crusan, Tanya M. Petterson, Kent R Bailey, John A. Heit

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Abstract

Objective: To test active cancer for an association with venous thromboembolism (VTE) location. Patients and Methods: Using the resources of the Rochester Epidemiology Project, we identified all Olmsted County, MN, residents with incident VTE during the 35-year period 1966-2000 (N=3385). We restricted analyses to residents with objectively diagnosed VTE during the 17-year period from January 1, 1984,to December 31, 2000 (N=1599). For each patient, we reviewed the complete medical records in the community for patient age, gender, and most recent body mass index at VTE onset; VTE event type and location; and previously identified independent VTE risk factors (ie, surgery, hospitalization for acute medical illness, active cancer, leg paresis, superficial venous thrombosis, and varicose veins). Using logistic regression we tested active cancer for an association with each of 4 symptomatic VTE locations (arm or intra-abdominal deep venous thrombosis [DVT], intra-abdominal DVT, pulmonary embolism, and bilateral leg DVT), adjusted for age, gender, body mass index, and other VTE risk factors. Results : In multivariate analyses, active cancer was independently associated with arm or intra-abdominal DVT (odds ratio [OR], 1.76; P=.01), intra-abdominal DVT (OR, 2.22; P=.004), and bilateral leg DVT (OR, 2.09; P=.02), but not pulmonary embolism (OR, 0.93). Conclusion: Active cancer is associated with VTE location. Location of VTE may be useful in decision making regarding cancer screening.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalMayo Clinic Proceedings
Volume86
Issue number1
DOIs
StatePublished - 2011

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Venous Thromboembolism
Venous Thrombosis
Population
Neoplasms
Odds Ratio
Leg
Pulmonary Embolism
Body Mass Index
Arm
Varicose Veins
Paresis
Early Detection of Cancer
Medical Records
Decision Making
Epidemiology
Hospitalization
Multivariate Analysis
Logistic Models

ASJC Scopus subject areas

  • Medicine(all)

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The association of active cancer with venous thromboembolism location : A population-based study. / Tafur, Alfonso J.; Kalsi, Henna; Wysokinski, Waldemar E.; McBane, Robert D.; Ashrani, Aneel Arjun; Marks, Randolph Stuart; Crusan, Daniel J.; Petterson, Tanya M.; Bailey, Kent R; Heit, John A.

In: Mayo Clinic Proceedings, Vol. 86, No. 1, 2011, p. 25-30.

Research output: Contribution to journalArticle

Tafur, Alfonso J. ; Kalsi, Henna ; Wysokinski, Waldemar E. ; McBane, Robert D. ; Ashrani, Aneel Arjun ; Marks, Randolph Stuart ; Crusan, Daniel J. ; Petterson, Tanya M. ; Bailey, Kent R ; Heit, John A. / The association of active cancer with venous thromboembolism location : A population-based study. In: Mayo Clinic Proceedings. 2011 ; Vol. 86, No. 1. pp. 25-30.
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abstract = "Objective: To test active cancer for an association with venous thromboembolism (VTE) location. Patients and Methods: Using the resources of the Rochester Epidemiology Project, we identified all Olmsted County, MN, residents with incident VTE during the 35-year period 1966-2000 (N=3385). We restricted analyses to residents with objectively diagnosed VTE during the 17-year period from January 1, 1984,to December 31, 2000 (N=1599). For each patient, we reviewed the complete medical records in the community for patient age, gender, and most recent body mass index at VTE onset; VTE event type and location; and previously identified independent VTE risk factors (ie, surgery, hospitalization for acute medical illness, active cancer, leg paresis, superficial venous thrombosis, and varicose veins). Using logistic regression we tested active cancer for an association with each of 4 symptomatic VTE locations (arm or intra-abdominal deep venous thrombosis [DVT], intra-abdominal DVT, pulmonary embolism, and bilateral leg DVT), adjusted for age, gender, body mass index, and other VTE risk factors. Results : In multivariate analyses, active cancer was independently associated with arm or intra-abdominal DVT (odds ratio [OR], 1.76; P=.01), intra-abdominal DVT (OR, 2.22; P=.004), and bilateral leg DVT (OR, 2.09; P=.02), but not pulmonary embolism (OR, 0.93). Conclusion: Active cancer is associated with VTE location. Location of VTE may be useful in decision making regarding cancer screening.",
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AU - Ashrani, Aneel Arjun

AU - Marks, Randolph Stuart

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