The antiobesity drug Orlistat induces cytotoxic effects, suppresses Her-2/neu (erbB-2) oncogene overexpression, and synergistically interacts with trastuzumab (Herceptin™) in chemoresistant ovarian cancer cells

J. A. Menendez, L. Vellon, Ruth Lupu

Research output: Contribution to journalArticle

26 Citations (Scopus)
Original languageEnglish (US)
Pages (from-to)219-221
Number of pages3
JournalInternational Journal of Gynecological Cancer
Volume16
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

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Neoplastic Gene Expression Regulation
Drug Dose Response Relationship
Drug Synergism
Anti-Obesity Agents
erbB-2 Genes
Lactones
Tumor Cell Line
Oncogenes
Ovarian Neoplasms
Monoclonal Antibodies
Carcinoma
Sensitivity and Specificity
Trastuzumab
orlistat

Keywords

  • Her-2/neu
  • Orlistat
  • Ovarian cancer

ASJC Scopus subject areas

  • Cancer Research
  • Obstetrics and Gynecology
  • Oncology

Cite this

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title = "The antiobesity drug Orlistat induces cytotoxic effects, suppresses Her-2/neu (erbB-2) oncogene overexpression, and synergistically interacts with trastuzumab (Herceptin™) in chemoresistant ovarian cancer cells",
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