The amino acid sequence of the NH2-terminal portion of rat and human vitamin D binding protein: Evidence for a high degree of homology between rat and human vitamin D binding protein

Robert Litwiller, David Fass, Rajiv Kumar

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Abstract

We determined the amino terminal sequence of rat and human vitamin D binding protein (VDBP). The sequences of the two proteins are: Rat VDBP: LeuGluArgGlyArgAspTyrGluLysAspLysValCysGlnGluLeuSerThrLeuGlyLys Human VDBP: LeuGluArgGlyArgAspTyrGluLysAsnLysValCysLysGluPheSerHisLeuGlyLys AspAspPhe GluAspPhe. There are 19 matches out of a total of 24 residues sequenced giving a percent match/lenght of 79.2%. Differences in the composition of the two proteins at residue 10, 14, 16, and 22 can be accounted for by single base changes in the the gene for the proteins. The difference (Thr→His) at residue 18 requires a change in two bases in the respective genes. We conclude that the sequence of the amino terminus of rat and human VDBP is similar with a high degree of homology between the two proteins.

Original languageEnglish (US)
Pages (from-to)2179-2184
Number of pages6
JournalLife Sciences
Volume38
Issue number24
DOIs
StatePublished - Jun 16 1986

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ASJC Scopus subject areas

  • Pharmacology

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