The amino acid sequence of the NH2-terminal portion of rat and human vitamin D binding protein: Evidence for a high degree of homology between rat and human vitamin D binding protein

Robert Litwiller; David Fass; Rajiv Kumar

doi:10.1016/0024-3205(86)90569-2

The amino acid sequence of the NH₂-terminal portion of rat and human vitamin D binding protein: Evidence for a high degree of homology between rat and human vitamin D binding protein

Robert Litwiller, David Fass, Rajiv Kumar

Nephrology and Hypertension

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We determined the amino terminal sequence of rat and human vitamin D binding protein (VDBP). The sequences of the two proteins are: Rat VDBP: LeuGluArgGlyArgAspTyrGluLysAspLysValCysGlnGluLeuSerThrLeuGlyLys Human VDBP: LeuGluArgGlyArgAspTyrGluLysAsnLysValCysLysGluPheSerHisLeuGlyLys AspAspPhe GluAspPhe. There are 19 matches out of a total of 24 residues sequenced giving a percent match/lenght of 79.2%. Differences in the composition of the two proteins at residue 10, 14, 16, and 22 can be accounted for by single base changes in the the gene for the proteins. The difference (Thr→His) at residue 18 requires a change in two bases in the respective genes. We conclude that the sequence of the amino terminus of rat and human VDBP is similar with a high degree of homology between the two proteins.

Original language	English (US)
Pages (from-to)	2179-2184
Number of pages	6
Journal	Life Sciences
Volume	38
Issue number	24
DOIs	https://doi.org/10.1016/0024-3205(86)90569-2
State	Published - Jun 16 1986

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(86)90569-2

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title = "The amino acid sequence of the NH2-terminal portion of rat and human vitamin D binding protein: Evidence for a high degree of homology between rat and human vitamin D binding protein",

abstract = "We determined the amino terminal sequence of rat and human vitamin D binding protein (VDBP). The sequences of the two proteins are: Rat VDBP: LeuGluArgGlyArgAspTyrGluLysAspLysValCysGlnGluLeuSerThrLeuGlyLys Human VDBP: LeuGluArgGlyArgAspTyrGluLysAsnLysValCysLysGluPheSerHisLeuGlyLys AspAspPhe GluAspPhe. There are 19 matches out of a total of 24 residues sequenced giving a percent match/lenght of 79.2%. Differences in the composition of the two proteins at residue 10, 14, 16, and 22 can be accounted for by single base changes in the the gene for the proteins. The difference (Thr→His) at residue 18 requires a change in two bases in the respective genes. We conclude that the sequence of the amino terminus of rat and human VDBP is similar with a high degree of homology between the two proteins.",

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T2 - Evidence for a high degree of homology between rat and human vitamin D binding protein

AU - Litwiller, Robert

AU - Fass, David

AU - Kumar, Rajiv

PY - 1986/6/16

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N2 - We determined the amino terminal sequence of rat and human vitamin D binding protein (VDBP). The sequences of the two proteins are: Rat VDBP: LeuGluArgGlyArgAspTyrGluLysAspLysValCysGlnGluLeuSerThrLeuGlyLys Human VDBP: LeuGluArgGlyArgAspTyrGluLysAsnLysValCysLysGluPheSerHisLeuGlyLys AspAspPhe GluAspPhe. There are 19 matches out of a total of 24 residues sequenced giving a percent match/lenght of 79.2%. Differences in the composition of the two proteins at residue 10, 14, 16, and 22 can be accounted for by single base changes in the the gene for the proteins. The difference (Thr→His) at residue 18 requires a change in two bases in the respective genes. We conclude that the sequence of the amino terminus of rat and human VDBP is similar with a high degree of homology between the two proteins.

AB - We determined the amino terminal sequence of rat and human vitamin D binding protein (VDBP). The sequences of the two proteins are: Rat VDBP: LeuGluArgGlyArgAspTyrGluLysAspLysValCysGlnGluLeuSerThrLeuGlyLys Human VDBP: LeuGluArgGlyArgAspTyrGluLysAsnLysValCysLysGluPheSerHisLeuGlyLys AspAspPhe GluAspPhe. There are 19 matches out of a total of 24 residues sequenced giving a percent match/lenght of 79.2%. Differences in the composition of the two proteins at residue 10, 14, 16, and 22 can be accounted for by single base changes in the the gene for the proteins. The difference (Thr→His) at residue 18 requires a change in two bases in the respective genes. We conclude that the sequence of the amino terminus of rat and human VDBP is similar with a high degree of homology between the two proteins.

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The amino acid sequence of the NH₂-terminal portion of rat and human vitamin D binding protein: Evidence for a high degree of homology between rat and human vitamin D binding protein

Abstract

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