TY - JOUR
T1 - Tests of muscle strength and physical function
T2 - Reliability and discrimination of performance in younger and older men and older men with mobility limitations
AU - LeBrasseur, Nathan K.
AU - Bhasin, Shalender
AU - Miciek, Renee
AU - Storer, Thomas W.
PY - 2008/11
Y1 - 2008/11
N2 - OBJECTIVES: To compare the reliability of muscle strength and physical function measures in younger and older men. DESIGN: Cross-sectional. SETTING: Academic research center. PARTICIPANTS: Thirty younger men, 31 older men, and 39 older men with mobility limitations. MEASUREMENTS: Test-retest measures of one repetition maximum (1 RM), unloaded and loaded 50-m walk and stair climb, and a lift-and-lower task. Reliability was assessed using intraclass correlation (ICC) analysis and the Bland-Altman method. RESULTS: Leg and chest press 1 RM measures identified significant differences between the groups, exhibited excellent test-retest reliability in younger men, older men, and older men with mobility limitations (ICCs=0.946-0.994) and minimal bias between Trials 1 and 2 (Bland-Altman=improvement of 21.1 and 1.1 N for leg and chest press, respectively). Test-retest measures of the time to walk 50 m and climb 12 steps also demonstrated excellent agreement (ICCs=0.980-0.988 and 0.942-992, respectively) and minimal bias (Bland-Altman=0.755-1.007 and 0.141-0.361 seconds faster, respectively). When a subject repeated these measures carrying a modest load, ICCs remained greater than 0.940, bias was similar, and the tests better discriminated between the groups. The lift-and-lower measure demonstrated excellent agreement (ICCs=0.925-0.947) and minimal bias (1.4-2.9 more shelves) and revealed significant differences between groups. CONCLUSION: Measures of muscle strength and physical function can be performed in younger men, older men, and older men with mobility limitations with high reliability. In future clinical trials, more-challenging measures of performance may better discriminate between higher-functioning study participants.
AB - OBJECTIVES: To compare the reliability of muscle strength and physical function measures in younger and older men. DESIGN: Cross-sectional. SETTING: Academic research center. PARTICIPANTS: Thirty younger men, 31 older men, and 39 older men with mobility limitations. MEASUREMENTS: Test-retest measures of one repetition maximum (1 RM), unloaded and loaded 50-m walk and stair climb, and a lift-and-lower task. Reliability was assessed using intraclass correlation (ICC) analysis and the Bland-Altman method. RESULTS: Leg and chest press 1 RM measures identified significant differences between the groups, exhibited excellent test-retest reliability in younger men, older men, and older men with mobility limitations (ICCs=0.946-0.994) and minimal bias between Trials 1 and 2 (Bland-Altman=improvement of 21.1 and 1.1 N for leg and chest press, respectively). Test-retest measures of the time to walk 50 m and climb 12 steps also demonstrated excellent agreement (ICCs=0.980-0.988 and 0.942-992, respectively) and minimal bias (Bland-Altman=0.755-1.007 and 0.141-0.361 seconds faster, respectively). When a subject repeated these measures carrying a modest load, ICCs remained greater than 0.940, bias was similar, and the tests better discriminated between the groups. The lift-and-lower measure demonstrated excellent agreement (ICCs=0.925-0.947) and minimal bias (1.4-2.9 more shelves) and revealed significant differences between groups. CONCLUSION: Measures of muscle strength and physical function can be performed in younger men, older men, and older men with mobility limitations with high reliability. In future clinical trials, more-challenging measures of performance may better discriminate between higher-functioning study participants.
KW - Aging
KW - Anabolic therapies
KW - Muscle strength
KW - Physical function
KW - Sarcopenia
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U2 - 10.1111/j.1532-5415.2008.01953.x
DO - 10.1111/j.1532-5415.2008.01953.x
M3 - Article
C2 - 18811607
AN - SCOPUS:55349096126
SN - 0002-8614
VL - 56
SP - 2118
EP - 2123
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 11
ER -