Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats

Licy L. Yanes, Julio Sartori Valinotti, Radu Iliescu, Damian G. Romero, Lorraine C. Racusen, Huimin Zhang, Jane F. Reckelhoff

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Blood pressure (BP) is more salt sensitive in men than in premenopausal women. In Dahl salt-sensitive rats (DS), high-salt (HS) diet increases BP more in males than females. In contrast to the systemic renin-angiotensin system, which is suppressed in response to HS in male DS, intrarenal angiotensinogen expression is increased, and intrarenal levels of ANG II are not suppressed. In this study, the hypothesis was tested that there is a sexual dimorphism in HS-induced upregulation of intrarenal angiotensinogen mediated by testosterone that also causes increases in BP and renal injury. On a low-salt (LS) diet, male DS had higher levels of intrarenal angiotensinogen mRNA than females. HS diet for 4 wk increased renal cortical angiotensinogen mRNA and protein only in male DS, which was prevented by castration. Ovariectomy of female DS had no effect on intrarenal angiotensinogen expression on either diet. Radiotelemetric BP was similar between males and castrated rats on LS diet. HS diet for 4 wk caused a progressive increase in BP, protein and albumin excretion, and glomerular sclerosis in male DS rats, which were attenuated by castration. Testosterone replacement in castrated DS rats increased BP, renal injury, and upregulation of renal angiotensinogen associated with HS diet. Testosterone contributes to the development of hypertension and renal injury in male DS rats on HS diet possibly through upregulation of the intrarenal renin-angiotensin system.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Renal Physiology
Volume296
Issue number4
DOIs
StatePublished - Apr 1 2009
Externally publishedYes

Fingerprint

Inbred Dahl Rats
Angiotensinogen
Testosterone
Up-Regulation
Salts
Hypertension
Diet
Blood Pressure
Kidney
Sodium-Restricted Diet
Castration
Renin-Angiotensin System
Wounds and Injuries
Messenger RNA
Renal Hypertension
Ovariectomy
Sclerosis
Sex Characteristics
Blood Proteins
Albumins

Keywords

  • Androgens
  • Angiotensinogen
  • Glomerular sclerosis
  • Hypertension
  • Renal injury

ASJC Scopus subject areas

  • Physiology
  • Urology

Cite this

Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats. / Yanes, Licy L.; Sartori Valinotti, Julio; Iliescu, Radu; Romero, Damian G.; Racusen, Lorraine C.; Zhang, Huimin; Reckelhoff, Jane F.

In: American Journal of Physiology - Renal Physiology, Vol. 296, No. 4, 01.04.2009.

Research output: Contribution to journalArticle

Yanes, Licy L. ; Sartori Valinotti, Julio ; Iliescu, Radu ; Romero, Damian G. ; Racusen, Lorraine C. ; Zhang, Huimin ; Reckelhoff, Jane F. / Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats. In: American Journal of Physiology - Renal Physiology. 2009 ; Vol. 296, No. 4.
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