Testicular vein thrombosis: Incidence of recurrent venous thromboembolism and survival

Charles J. Lenz, Robert D. McBane, Kevin P. Cohoon, Dawid T. Janczak, Benjamin S. Simmons, Rayya A. Saadiq, Malgorzata Mimier, Ana I. Casanegra, Paul R. Daniels, Waldemar E. Wysokinski

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Testicular vein thrombosis (TVT) etiology, recurrence, and survival were compared with lower extremity deep vein thrombosis (DVT) in order to determine whether treatment guidelines for DVT could be applied to TVT. Patients and Methods: An inception cohort of patients with confirmed TVT (January 1995-October 2015) was compared to a control group of patients with lower extremity DVT matched by age, gender, and diagnosis date. Results: Thirty-nine men with TVT were identified; 15 (38%) with isolated TVT. Left testicular vein was affected in 77% patients; there were no cases of bilateral TVT. Cancer was over twofold more common in TVT patients (59% vs 28%, P =.01). Most cancers (78%) involved organs in proximity to the testicular vein. Although TVT patients were less frequently treated with anticoagulants (49% vs 97%, P =.0001), recurrence rates were similar to DVT group (TVT 4.2 vs DVT 1.1 per 100 patient-years, P =.11). Despite higher cancer prevalence, survival rates were similar between groups (31% vs 28%; P =.34). Major bleeding events were rare (one patient per group). Conclusions: Identifying TVT should prompt a search for a regional malignancy. Despite the high cancer prevalence and low utilization of anticoagulants, recurrent venous thrombosis and mortality rates are similar to DVT patients.

Original languageEnglish (US)
Pages (from-to)83-87
Number of pages5
JournalEuropean Journal of Haematology
Volume100
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Venous Thromboembolism
Veins
Thrombosis
Survival
Venous Thrombosis
Incidence
Neoplasms
Anticoagulants
Lower Extremity
Recurrence
Survival Rate
Guidelines
Hemorrhage

Keywords

  • risk factors
  • survival
  • testicular vein thrombosis
  • thrombosis recurrence

ASJC Scopus subject areas

  • Hematology

Cite this

Lenz, C. J., McBane, R. D., Cohoon, K. P., Janczak, D. T., Simmons, B. S., Saadiq, R. A., ... Wysokinski, W. E. (2018). Testicular vein thrombosis: Incidence of recurrent venous thromboembolism and survival. European Journal of Haematology, 100(1), 83-87. https://doi.org/10.1111/ejh.12985

Testicular vein thrombosis : Incidence of recurrent venous thromboembolism and survival. / Lenz, Charles J.; McBane, Robert D.; Cohoon, Kevin P.; Janczak, Dawid T.; Simmons, Benjamin S.; Saadiq, Rayya A.; Mimier, Malgorzata; Casanegra, Ana I.; Daniels, Paul R.; Wysokinski, Waldemar E.

In: European Journal of Haematology, Vol. 100, No. 1, 01.01.2018, p. 83-87.

Research output: Contribution to journalArticle

Lenz, CJ, McBane, RD, Cohoon, KP, Janczak, DT, Simmons, BS, Saadiq, RA, Mimier, M, Casanegra, AI, Daniels, PR & Wysokinski, WE 2018, 'Testicular vein thrombosis: Incidence of recurrent venous thromboembolism and survival', European Journal of Haematology, vol. 100, no. 1, pp. 83-87. https://doi.org/10.1111/ejh.12985
Lenz CJ, McBane RD, Cohoon KP, Janczak DT, Simmons BS, Saadiq RA et al. Testicular vein thrombosis: Incidence of recurrent venous thromboembolism and survival. European Journal of Haematology. 2018 Jan 1;100(1):83-87. https://doi.org/10.1111/ejh.12985
Lenz, Charles J. ; McBane, Robert D. ; Cohoon, Kevin P. ; Janczak, Dawid T. ; Simmons, Benjamin S. ; Saadiq, Rayya A. ; Mimier, Malgorzata ; Casanegra, Ana I. ; Daniels, Paul R. ; Wysokinski, Waldemar E. / Testicular vein thrombosis : Incidence of recurrent venous thromboembolism and survival. In: European Journal of Haematology. 2018 ; Vol. 100, No. 1. pp. 83-87.
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abstract = "Purpose: Testicular vein thrombosis (TVT) etiology, recurrence, and survival were compared with lower extremity deep vein thrombosis (DVT) in order to determine whether treatment guidelines for DVT could be applied to TVT. Patients and Methods: An inception cohort of patients with confirmed TVT (January 1995-October 2015) was compared to a control group of patients with lower extremity DVT matched by age, gender, and diagnosis date. Results: Thirty-nine men with TVT were identified; 15 (38{\%}) with isolated TVT. Left testicular vein was affected in 77{\%} patients; there were no cases of bilateral TVT. Cancer was over twofold more common in TVT patients (59{\%} vs 28{\%}, P =.01). Most cancers (78{\%}) involved organs in proximity to the testicular vein. Although TVT patients were less frequently treated with anticoagulants (49{\%} vs 97{\%}, P =.0001), recurrence rates were similar to DVT group (TVT 4.2 vs DVT 1.1 per 100 patient-years, P =.11). Despite higher cancer prevalence, survival rates were similar between groups (31{\%} vs 28{\%}; P =.34). Major bleeding events were rare (one patient per group). Conclusions: Identifying TVT should prompt a search for a regional malignancy. Despite the high cancer prevalence and low utilization of anticoagulants, recurrent venous thrombosis and mortality rates are similar to DVT patients.",
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