Tendon and ligament tissue engineering

Spencer P. Lake; Qian Liu; Malcolm Xing; Leanne E. Iannucci; Zhanwen Wang; Chunfeng Zhao

doi:10.1016/B978-0-12-818422-6.00056-3

Tendon and ligament tissue engineering

Spencer P. Lake, Qian Liu, Malcolm Xing, Leanne E. Iannucci, Zhanwen Wang, Chunfeng Zhao

Orthopedic Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Tendon and ligament are the major stabilizers in musculoskeletal system. Tendon/ligament injuries are common, especially in young generation. Loss of tendon/ligament support leads to tremendous functional disability. Thus restoration of tendon/ligament function after injury becomes crucial. However, the self-repair or regenerative capability of tendon/ligament is low due to their hypocellular and hypovascular nature. Therefore tissue engineering approaches to enhance tendon/ligament repair and regeneration or replace a nonrepairable tendon/ligament has indeed shed light on the future in this field. In this chapter the typical tissue-engineered tendon/ligament approaches with the basic elements and cutting edge technologies are discussed.

Original language	English (US)
Title of host publication	Principles of Tissue Engineering
Publisher	Elsevier
Pages	989-1005
Number of pages	17
ISBN (Electronic)	9780128184226
DOIs	https://doi.org/10.1016/B978-0-12-818422-6.00056-3
State	Published - Jan 1 2020

Keywords

3D bioprinting
Growth factor
Ligament
Scaffold
Stem cell
Tendon
Tissue engineering

ASJC Scopus subject areas

General Economics, Econometrics and Finance
General Business, Management and Accounting

Access to Document

10.1016/B978-0-12-818422-6.00056-3

Cite this

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abstract = "Tendon and ligament are the major stabilizers in musculoskeletal system. Tendon/ligament injuries are common, especially in young generation. Loss of tendon/ligament support leads to tremendous functional disability. Thus restoration of tendon/ligament function after injury becomes crucial. However, the self-repair or regenerative capability of tendon/ligament is low due to their hypocellular and hypovascular nature. Therefore tissue engineering approaches to enhance tendon/ligament repair and regeneration or replace a nonrepairable tendon/ligament has indeed shed light on the future in this field. In this chapter the typical tissue-engineered tendon/ligament approaches with the basic elements and cutting edge technologies are discussed.",

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AU - Liu, Qian

AU - Xing, Malcolm

AU - Iannucci, Leanne E.

AU - Wang, Zhanwen

AU - Zhao, Chunfeng

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AB - Tendon and ligament are the major stabilizers in musculoskeletal system. Tendon/ligament injuries are common, especially in young generation. Loss of tendon/ligament support leads to tremendous functional disability. Thus restoration of tendon/ligament function after injury becomes crucial. However, the self-repair or regenerative capability of tendon/ligament is low due to their hypocellular and hypovascular nature. Therefore tissue engineering approaches to enhance tendon/ligament repair and regeneration or replace a nonrepairable tendon/ligament has indeed shed light on the future in this field. In this chapter the typical tissue-engineered tendon/ligament approaches with the basic elements and cutting edge technologies are discussed.

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KW - Ligament

KW - Scaffold

KW - Stem cell

KW - Tendon

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Tendon and ligament tissue engineering

Abstract

Keywords

ASJC Scopus subject areas

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