Temporal Structure of In Vivo Adrenal Secretory Activity Estimated by Deconvolution Analysis

Johannes D. Veldhuis, Michael L. Johnson, Ali Iranmanesh, German Lizarralde

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Circadian and ultradian rhythms of plasma cortisol concentrations have been documented under physiological conditions in diverse animal species. Using a novel, biophysical convolution model to remove subject-specific metabolic clearance rates, we have now estimated spontaneous adrenal secretory events in vivo. The latter were characterized by prominent ultradian rhythms of discrete secretory bursts with periodicities averaging 32, 46, 76, and 130 min. These ultradian cortisol secretory rhythms represented a 17- to 240-fold larger fraction of circadian secretory variations than did cortisol concentration rhythms. We conclude that deconvolution analysis can unmask underlying ultradian rhythms in adrenal secretory activity in vivo.

Original languageEnglish (US)
Pages (from-to)247-255
Number of pages9
JournalJournal of biological rhythms
Volume5
Issue number3
DOIs
StatePublished - Sep 1990

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Temporal Structure of In Vivo Adrenal Secretory Activity Estimated by Deconvolution Analysis'. Together they form a unique fingerprint.

  • Cite this