Temporal structure of in vivo adrenal secretory activity estimated by deconvolution analysis.

Johannes D Veldhuis, M. L. Johnson, A. Iranmanesh, G. Lizarralde

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Circadian and ultradian rhythms of plasma cortisol concentrations have been documented under physiological conditions in diverse animal species. Using a novel, biophysical convolution model to remove subject-specific metabolic clearance rates, we have now estimated spontaneous adrenal secretory events in vivo. The latter were characterized by prominent ultradian rhythms of discrete secretory bursts with periodicities averaging 32, 46, 76, and 130 min. These ultradian cortisol secretory rhythms represented a 17- to 240-fold larger fraction of circadian secretory variations than did cortisol concentration rhythms. We conclude that deconvolution analysis can unmask underlying ultradian rhythms in adrenal secretory activity in vivo.

Original languageEnglish (US)
Pages (from-to)247-255
Number of pages9
JournalJournal of Biological Rhythms
Volume5
Issue number3
StatePublished - Sep 1990
Externally publishedYes

Fingerprint

ultradian rhythm
cortisol
Hydrocortisone
Metabolic Clearance Rate
Periodicity
Circadian Rhythm
periodicity
circadian rhythm
Ultradian Rhythm
animals

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Physiology
  • Physiology (medical)

Cite this

Veldhuis, J. D., Johnson, M. L., Iranmanesh, A., & Lizarralde, G. (1990). Temporal structure of in vivo adrenal secretory activity estimated by deconvolution analysis. Journal of Biological Rhythms, 5(3), 247-255.

Temporal structure of in vivo adrenal secretory activity estimated by deconvolution analysis. / Veldhuis, Johannes D; Johnson, M. L.; Iranmanesh, A.; Lizarralde, G.

In: Journal of Biological Rhythms, Vol. 5, No. 3, 09.1990, p. 247-255.

Research output: Contribution to journalArticle

Veldhuis, JD, Johnson, ML, Iranmanesh, A & Lizarralde, G 1990, 'Temporal structure of in vivo adrenal secretory activity estimated by deconvolution analysis.', Journal of Biological Rhythms, vol. 5, no. 3, pp. 247-255.
Veldhuis, Johannes D ; Johnson, M. L. ; Iranmanesh, A. ; Lizarralde, G. / Temporal structure of in vivo adrenal secretory activity estimated by deconvolution analysis. In: Journal of Biological Rhythms. 1990 ; Vol. 5, No. 3. pp. 247-255.
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