Telomerase as a diagnostic and therapeutic target for cancer

L. Austin Doyle, W. Edward Highsmith

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Telomerase is a ribonucleoprotein enzyme responsible for the elongation of telomeres at the ends of chromosomes. It is widely expressed in most cancers, while absent from most normal somatic cells. Telomerase is partially responsible for the cellular immortalization that allows human cancers to progress indefinitely. Due to its widespread occurrence in cancer and its crucial role in the maintenance of the tumor, telomerase is an attractive target for cancer diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)217-225
Number of pages9
JournalExpert review of anticancer therapy
Volume2
Issue number2
DOIs
StatePublished - Jan 1 2002

Keywords

  • Antisense RNA
  • Ribonucleoprotein
  • Ribozyme
  • Telomerase
  • Telomere

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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