Telomerase as a diagnostic and therapeutic target for cancer

L. Austin Doyle; W. Edward Highsmith

doi:10.1586/14737140.2.2.217

Telomerase as a diagnostic and therapeutic target for cancer

L. Austin Doyle, W. Edward Highsmith

Laboratory Medicine and Pathology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Telomerase is a ribonucleoprotein enzyme responsible for the elongation of telomeres at the ends of chromosomes. It is widely expressed in most cancers, while absent from most normal somatic cells. Telomerase is partially responsible for the cellular immortalization that allows human cancers to progress indefinitely. Due to its widespread occurrence in cancer and its crucial role in the maintenance of the tumor, telomerase is an attractive target for cancer diagnosis and treatment.

Original language	English (US)
Pages (from-to)	217-225
Number of pages	9
Journal	Expert review of anticancer therapy
Volume	2
Issue number	2
DOIs	https://doi.org/10.1586/14737140.2.2.217
State	Published - 2002

Keywords

Antisense RNA
Ribonucleoprotein
Ribozyme
Telomerase
Telomere

ASJC Scopus subject areas

Oncology
Pharmacology (medical)

Access to Document

10.1586/14737140.2.2.217

Cite this

@article{4180682aa0624de0b6f7c78e0cb14c35,

title = "Telomerase as a diagnostic and therapeutic target for cancer",

abstract = "Telomerase is a ribonucleoprotein enzyme responsible for the elongation of telomeres at the ends of chromosomes. It is widely expressed in most cancers, while absent from most normal somatic cells. Telomerase is partially responsible for the cellular immortalization that allows human cancers to progress indefinitely. Due to its widespread occurrence in cancer and its crucial role in the maintenance of the tumor, telomerase is an attractive target for cancer diagnosis and treatment.",

keywords = "Antisense RNA, Ribonucleoprotein, Ribozyme, Telomerase, Telomere",

author = "Doyle, {L. Austin} and Highsmith, {W. Edward}",

year = "2002",

doi = "10.1586/14737140.2.2.217",

language = "English (US)",

volume = "2",

pages = "217--225",

journal = "Expert review of anticancer therapy",

issn = "1473-7140",

publisher = "Expert Reviews Ltd.",

number = "2",

}

TY - JOUR

T1 - Telomerase as a diagnostic and therapeutic target for cancer

AU - Doyle, L. Austin

AU - Highsmith, W. Edward

PY - 2002

Y1 - 2002

N2 - Telomerase is a ribonucleoprotein enzyme responsible for the elongation of telomeres at the ends of chromosomes. It is widely expressed in most cancers, while absent from most normal somatic cells. Telomerase is partially responsible for the cellular immortalization that allows human cancers to progress indefinitely. Due to its widespread occurrence in cancer and its crucial role in the maintenance of the tumor, telomerase is an attractive target for cancer diagnosis and treatment.

AB - Telomerase is a ribonucleoprotein enzyme responsible for the elongation of telomeres at the ends of chromosomes. It is widely expressed in most cancers, while absent from most normal somatic cells. Telomerase is partially responsible for the cellular immortalization that allows human cancers to progress indefinitely. Due to its widespread occurrence in cancer and its crucial role in the maintenance of the tumor, telomerase is an attractive target for cancer diagnosis and treatment.

KW - Antisense RNA

KW - Ribonucleoprotein

KW - Ribozyme

KW - Telomerase

KW - Telomere

UR - http://www.scopus.com/inward/record.url?scp=0036084491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036084491&partnerID=8YFLogxK

U2 - 10.1586/14737140.2.2.217

DO - 10.1586/14737140.2.2.217

M3 - Review article

C2 - 12113243

AN - SCOPUS:0036084491

SN - 1473-7140

VL - 2

SP - 217

EP - 225

JO - Expert review of anticancer therapy

JF - Expert review of anticancer therapy

IS - 2

ER -

Telomerase as a diagnostic and therapeutic target for cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this