Technical failure of MR elastography examinations of the liver: Experience from a large single-center study

Mathilde Wagner, Idoia Corcuera-Solano, Grace Lo, Steven Esses, Joseph Liao, Cecilia Besa, Nelson Chen, Ginu Abraham, Maggie Fung, James S. Babb, Richard Lorne Ehman, Bachir Taouli

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Abstract

Purpose: To assess the determinants of technical failure of magnetic resonance (MR) elastography of the liver in a large singlecenter study. Materials and Methods: This retrospective study was approved by the institutional review board. Seven hundred eighty-one MR elastography examinations performed in 691 consecutive patients (mean age, 58 years; male patients, 434 [62.8%]) in a single center between June 2013 and August 2014 were retrospectively evaluated. MR elastography was performed at 3.0 T (n = 443) or 1.5 T (n = 338) by using a gradientrecalled-echo pulse sequence. MR elastography and anatomic image analysis were performed by two observers. Additional observers measured liver T2∗and fat fraction. Technical failure was defined as no pixel value with a confidence index higher than 95% and/or no apparent shear waves imaged. Logistic regression analysis was performed to assess potential predictive factors of technical failure of MR elastography. Results: The technical failure rate of MR elastography at 1.5 T was 3.5% (12 of 338), while it was higher, 15.3% (68 of 443), at 3.0 T. On the basis of univariate analysis, body mass index, liver iron deposition, massive ascites, use of 3.0 T, presence of cirrhosis, and alcoholic liver disease were all significantly associated with failure of MR elastography (P < .004); but on the basis of multivariable analysis, only body mass index, liver iron deposition, massive ascites, and use of 3.0 T were significantly associated with failure of MR elastography (P < .004). Conclusion: The technical failure rate of MR elastography with a gradient-recalled-echo pulse sequence was low at 1.5 T but substantially higher at 3.0 T. Massive ascites, iron deposition, and high body mass index were additional independent factors associated with failure of MR elastography of the liver with a two-dimensional gradient-recalled-echo pulse sequence.

Original languageEnglish (US)
Pages (from-to)401-412
Number of pages12
JournalRadiology
Volume284
Issue number2
DOIs
StatePublished - Aug 1 2017

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Elasticity Imaging Techniques
Liver
Ascites
Body Mass Index
Iron
Alcoholic Liver Diseases
Research Ethics Committees
Fibrosis
Retrospective Studies
Logistic Models
Fats
Regression Analysis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Wagner, M., Corcuera-Solano, I., Lo, G., Esses, S., Liao, J., Besa, C., ... Taouli, B. (2017). Technical failure of MR elastography examinations of the liver: Experience from a large single-center study. Radiology, 284(2), 401-412. https://doi.org/10.1148/radiol.2016160863

Technical failure of MR elastography examinations of the liver : Experience from a large single-center study. / Wagner, Mathilde; Corcuera-Solano, Idoia; Lo, Grace; Esses, Steven; Liao, Joseph; Besa, Cecilia; Chen, Nelson; Abraham, Ginu; Fung, Maggie; Babb, James S.; Ehman, Richard Lorne; Taouli, Bachir.

In: Radiology, Vol. 284, No. 2, 01.08.2017, p. 401-412.

Research output: Contribution to journalArticle

Wagner, M, Corcuera-Solano, I, Lo, G, Esses, S, Liao, J, Besa, C, Chen, N, Abraham, G, Fung, M, Babb, JS, Ehman, RL & Taouli, B 2017, 'Technical failure of MR elastography examinations of the liver: Experience from a large single-center study', Radiology, vol. 284, no. 2, pp. 401-412. https://doi.org/10.1148/radiol.2016160863
Wagner, Mathilde ; Corcuera-Solano, Idoia ; Lo, Grace ; Esses, Steven ; Liao, Joseph ; Besa, Cecilia ; Chen, Nelson ; Abraham, Ginu ; Fung, Maggie ; Babb, James S. ; Ehman, Richard Lorne ; Taouli, Bachir. / Technical failure of MR elastography examinations of the liver : Experience from a large single-center study. In: Radiology. 2017 ; Vol. 284, No. 2. pp. 401-412.
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abstract = "Purpose: To assess the determinants of technical failure of magnetic resonance (MR) elastography of the liver in a large singlecenter study. Materials and Methods: This retrospective study was approved by the institutional review board. Seven hundred eighty-one MR elastography examinations performed in 691 consecutive patients (mean age, 58 years; male patients, 434 [62.8{\%}]) in a single center between June 2013 and August 2014 were retrospectively evaluated. MR elastography was performed at 3.0 T (n = 443) or 1.5 T (n = 338) by using a gradientrecalled-echo pulse sequence. MR elastography and anatomic image analysis were performed by two observers. Additional observers measured liver T2∗and fat fraction. Technical failure was defined as no pixel value with a confidence index higher than 95{\%} and/or no apparent shear waves imaged. Logistic regression analysis was performed to assess potential predictive factors of technical failure of MR elastography. Results: The technical failure rate of MR elastography at 1.5 T was 3.5{\%} (12 of 338), while it was higher, 15.3{\%} (68 of 443), at 3.0 T. On the basis of univariate analysis, body mass index, liver iron deposition, massive ascites, use of 3.0 T, presence of cirrhosis, and alcoholic liver disease were all significantly associated with failure of MR elastography (P < .004); but on the basis of multivariable analysis, only body mass index, liver iron deposition, massive ascites, and use of 3.0 T were significantly associated with failure of MR elastography (P < .004). Conclusion: The technical failure rate of MR elastography with a gradient-recalled-echo pulse sequence was low at 1.5 T but substantially higher at 3.0 T. Massive ascites, iron deposition, and high body mass index were additional independent factors associated with failure of MR elastography of the liver with a two-dimensional gradient-recalled-echo pulse sequence.",
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T2 - Experience from a large single-center study

AU - Wagner, Mathilde

AU - Corcuera-Solano, Idoia

AU - Lo, Grace

AU - Esses, Steven

AU - Liao, Joseph

AU - Besa, Cecilia

AU - Chen, Nelson

AU - Abraham, Ginu

AU - Fung, Maggie

AU - Babb, James S.

AU - Ehman, Richard Lorne

AU - Taouli, Bachir

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N2 - Purpose: To assess the determinants of technical failure of magnetic resonance (MR) elastography of the liver in a large singlecenter study. Materials and Methods: This retrospective study was approved by the institutional review board. Seven hundred eighty-one MR elastography examinations performed in 691 consecutive patients (mean age, 58 years; male patients, 434 [62.8%]) in a single center between June 2013 and August 2014 were retrospectively evaluated. MR elastography was performed at 3.0 T (n = 443) or 1.5 T (n = 338) by using a gradientrecalled-echo pulse sequence. MR elastography and anatomic image analysis were performed by two observers. Additional observers measured liver T2∗and fat fraction. Technical failure was defined as no pixel value with a confidence index higher than 95% and/or no apparent shear waves imaged. Logistic regression analysis was performed to assess potential predictive factors of technical failure of MR elastography. Results: The technical failure rate of MR elastography at 1.5 T was 3.5% (12 of 338), while it was higher, 15.3% (68 of 443), at 3.0 T. On the basis of univariate analysis, body mass index, liver iron deposition, massive ascites, use of 3.0 T, presence of cirrhosis, and alcoholic liver disease were all significantly associated with failure of MR elastography (P < .004); but on the basis of multivariable analysis, only body mass index, liver iron deposition, massive ascites, and use of 3.0 T were significantly associated with failure of MR elastography (P < .004). Conclusion: The technical failure rate of MR elastography with a gradient-recalled-echo pulse sequence was low at 1.5 T but substantially higher at 3.0 T. Massive ascites, iron deposition, and high body mass index were additional independent factors associated with failure of MR elastography of the liver with a two-dimensional gradient-recalled-echo pulse sequence.

AB - Purpose: To assess the determinants of technical failure of magnetic resonance (MR) elastography of the liver in a large singlecenter study. Materials and Methods: This retrospective study was approved by the institutional review board. Seven hundred eighty-one MR elastography examinations performed in 691 consecutive patients (mean age, 58 years; male patients, 434 [62.8%]) in a single center between June 2013 and August 2014 were retrospectively evaluated. MR elastography was performed at 3.0 T (n = 443) or 1.5 T (n = 338) by using a gradientrecalled-echo pulse sequence. MR elastography and anatomic image analysis were performed by two observers. Additional observers measured liver T2∗and fat fraction. Technical failure was defined as no pixel value with a confidence index higher than 95% and/or no apparent shear waves imaged. Logistic regression analysis was performed to assess potential predictive factors of technical failure of MR elastography. Results: The technical failure rate of MR elastography at 1.5 T was 3.5% (12 of 338), while it was higher, 15.3% (68 of 443), at 3.0 T. On the basis of univariate analysis, body mass index, liver iron deposition, massive ascites, use of 3.0 T, presence of cirrhosis, and alcoholic liver disease were all significantly associated with failure of MR elastography (P < .004); but on the basis of multivariable analysis, only body mass index, liver iron deposition, massive ascites, and use of 3.0 T were significantly associated with failure of MR elastography (P < .004). Conclusion: The technical failure rate of MR elastography with a gradient-recalled-echo pulse sequence was low at 1.5 T but substantially higher at 3.0 T. Massive ascites, iron deposition, and high body mass index were additional independent factors associated with failure of MR elastography of the liver with a two-dimensional gradient-recalled-echo pulse sequence.

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