TY - JOUR
T1 - Tea consumption and risk of bladder and kidney cancers in a population-based case-control study
AU - Bianchi, Gregory D.
AU - Cerhan, James R.
AU - Parker, Alexander S.
AU - Putnam, Shannon D.
AU - See, William A.
AU - Lynch, Charles F.
AU - Cantor, Kenneth P.
N1 - Funding Information:
Supported by National Cancer Institute contracts NCI-NO1-CP-51026 and NCI-NO1-CP-85614. Dr. Cerhan was supported in part by a National Cancer Institute Preventive Oncology Academic Award (K07 CA64220).
PY - 2000/2/15
Y1 - 2000/2/15
N2 - Recent epidemiologic studies have suggested that tea may be protective against cancers of the urinary tract. The authors examined the association between usual adult tea consumption and risk of bladder and kidney cancers in a population-based case- control study that included 1,452 bladder cancer cases, 406 kidney cancer cases, and 2,434 controls. For bladder cancer, the age- and sex-adjusted odds ratios (OR) (95% confidence intervals (CI)) referent to nonusers of tea were 0.9 (0.7, 1.1) for <1.0 cup/day, 1.0 (0.8, 1.2) for 1.0-2.6 cups/day, and 0.9 (0.7, 1.1) for >2.6 cups/day (cutpoints for users based on the tertile distribution among controls). When more extreme cutpoints were used, persons who consumed >5 cups/day (>90th percentile) had a suggestive decreased risk (OR = 0.7; 95% CI 0.5, 1.0), but there was no evidence of a dose-response relation. In analyses stratified by median total beverage intake (2.6 liters/day), there was an inverse association with tea use among persons who consumed less than the median (OR = 0.5; 95% CI 0.3, 0.8) but no association for persons who consumed at or above the median. In contrast, for kidney cancer, there was no association with tea use. Adjustment for site-specific risk factors did not alter these results. This study offers only minimal support for an inverse association between tea consumption and bladder or kidney cancer risk.
AB - Recent epidemiologic studies have suggested that tea may be protective against cancers of the urinary tract. The authors examined the association between usual adult tea consumption and risk of bladder and kidney cancers in a population-based case- control study that included 1,452 bladder cancer cases, 406 kidney cancer cases, and 2,434 controls. For bladder cancer, the age- and sex-adjusted odds ratios (OR) (95% confidence intervals (CI)) referent to nonusers of tea were 0.9 (0.7, 1.1) for <1.0 cup/day, 1.0 (0.8, 1.2) for 1.0-2.6 cups/day, and 0.9 (0.7, 1.1) for >2.6 cups/day (cutpoints for users based on the tertile distribution among controls). When more extreme cutpoints were used, persons who consumed >5 cups/day (>90th percentile) had a suggestive decreased risk (OR = 0.7; 95% CI 0.5, 1.0), but there was no evidence of a dose-response relation. In analyses stratified by median total beverage intake (2.6 liters/day), there was an inverse association with tea use among persons who consumed less than the median (OR = 0.5; 95% CI 0.3, 0.8) but no association for persons who consumed at or above the median. In contrast, for kidney cancer, there was no association with tea use. Adjustment for site-specific risk factors did not alter these results. This study offers only minimal support for an inverse association between tea consumption and bladder or kidney cancer risk.
KW - Bladder neoplasms
KW - Case-control studies
KW - Diet
KW - Kidney neoplasms
KW - Tea
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U2 - 10.1093/oxfordjournals.aje.a010217
DO - 10.1093/oxfordjournals.aje.a010217
M3 - Article
C2 - 10695596
AN - SCOPUS:0034651505
SN - 0002-9262
VL - 151
SP - 377
EP - 383
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 4
ER -