Tauopathies with parkinsonism: Clinical spectrum, neuropathologic basis, biological markers, and treatment options

A. C. Ludolph, J. Kassubek, B. G. Landwehrmeyer, E. Mandelkow, E. M. Mandelkow, D. J. Burn, D. Caparros-Lefebvre, K. A. Frey, J. G. De Yebenes, T. Gasser, P. Heutink, G. Höglinger, Z. Jamrozik, K. A. Jellinger, A. Kazantsev, H. Kretzschmar, A. E. Lang, I. Litvan, J. J. Lucas, P. L. McGeerS. Melquist, W. Oertel, M. Otto, D. Paviour, T. Reum, A. Saint-Raymond, J. C. Steele, M. Tolnay, H. Tumani, J. C. Van Swieten, M. T. Vanier, J. P. Vonsattel, S. Wagner, Z. K. Wszolek

Research output: Contribution to journalReview articlepeer-review

136 Scopus citations

Abstract

Tauopathies with parkinsonism represent a spectrum of disease entities unified by the pathologic accumulation of hyperphosphorylated tau protein fragments within the central nervous system. These pathologic characteristics suggest shared pathogenetic pathways and possible molecular targets for disease-modifying therapeutic interventions. Natural history studies, for instance, in progressive supranuclear palsy, frontotemporal dementia with parkinsonism linked to chromosome 17, corticobasal degeneration, and Niemann-Pick disease type C as well as in amyotrophic lateral sclerosis/Parkinson-dementia complex permit clinical characterization of the disease phenotypes and are crucial to the development and validation of biological markers for differential diagnostics and disease monitoring, for example, by use of neuroimaging or proteomic approaches. The wide pathologic and clinical spectrum of the tauopathies with parkinsonism is reviewed in this article, and perspectives on future advances in the understanding of the pathogenesis are given, together with potential therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)297-309
Number of pages13
JournalEuropean Journal of Neurology
Volume16
Issue number3
DOIs
StatePublished - Mar 2009

Keywords

  • Corticobasal degeneration
  • Frontotemporal dementia with parkinsonism linked to chromosome 17
  • Microtubule-associated protein tau
  • Multiple system atrophy
  • Parkinson disease
  • Parkinsonism
  • Progressive supranuclear palsy
  • Tauopathies

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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