Tauopathies: Classification, Clinical Features, and Genetics

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Neurodegenerative diseases are characterized by the deposition of biochemically abnormal proteins. One such protein is the microtubule-associated protein tau. Neurodegenerative diseases, in which tau is the major, or predominant, deposited protein, are termed tauopathies. Many tauopathies are associated with movement disorders as part of the presenting syndromes. The most common tauopathies associated with movement disorders are progressive supranuclear palsy, corticobasal degeneration, and frontotemporal dementia with parkinsonism linked to chromosome 17. Less common tauopathies include postencephalic parkinsonism and globular glial tauopathy. All five tauopathies are associated with indistinct clinical syndromes that may have overlapping symptoms. However, some syndromes are more likely to be associated with certain tauopathies. Imaging patterns of abnormalities and genetic aberrations have been described for each of the tauopathies. This chapter focuses on the classification, clinical, and genetic features of these five tauopathies.

Original languageEnglish (US)
Title of host publicationMovement Disorders: Genetics and Models: Second Edition
PublisherElsevier Inc.
Pages817-828
Number of pages12
ISBN (Print)9780124051959
DOIs
StatePublished - Oct 29 2014

Keywords

  • Argyrophilic grain disease
  • Corticobasal degeneration
  • Pallidopontonigral degeneration
  • Parkinsonism dementia complex of Guam
  • Postencephalic parkinsonism globular glial tauopathy
  • Progressive supranuclear palsy

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Josephs, K. A. (2014). Tauopathies: Classification, Clinical Features, and Genetics. In Movement Disorders: Genetics and Models: Second Edition (pp. 817-828). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-405195-9.00053-6