Tau uptake in agrammatic primary progressive aphasia with and without apraxia of speech

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Abstract

Background and purpose: The non-fluent/agrammatic variant of primary progressive aphasia (agPPA) is a heterogeneous diagnosis wherein some individuals have apraxia of speech (AOS). When agPPA includes AOS, a tauopathy is the likely underlying pathology. Recently, [18F]AV-1451 was developed for the in-vivo assessment of tau. In this study, we compared patterns of tau tracer uptake in patients with agPPA with and without AOS. Methods: Nine patients with agPPA (four without AOS) underwent tau positron emission tomography imaging with [18F]AV-1451. Uptake of [18F]AV-1451 was assessed as cortical to cerebellar crus ratio (standard uptake value ratio) in cortical regions of interest measured using the MCALT atlas and compared voxel-wise in SPM12. Each patient was age- and sex-matched to three controls. Results: The agPPA without AOS showed uptake in the left frontal and temporal lobes, whereas agPPA with AOS showed uptake in the bilateral supplementary motor areas, frontal lobes, precuneus and precentral gyrus relative to controls. The left precentral gyrus had uptake in agPPA with AOS relative to those without AOS. Conclusions: This cross-sectional study suggests that [18F]AV-1451 uptake in the precentral gyrus is implicated in AOS in agPPA.

Original languageEnglish (US)
Pages (from-to)1352-1357
Number of pages6
JournalEuropean Journal of Neurology
Volume25
Issue number11
DOIs
StatePublished - Nov 1 2018

Fingerprint

Primary Progressive Aphasia
Apraxias
Frontal Lobe
Tauopathies
Parietal Lobe
Atlases
Motor Cortex
Temporal Lobe
Positron-Emission Tomography
Cross-Sectional Studies

Keywords

  • apraxia of speech
  • primary progressive aphasia
  • tau positron emission tomography
  • [18F]AV-1451

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

@article{1ee8cbd439c947da8af73cdef2eefed9,
title = "Tau uptake in agrammatic primary progressive aphasia with and without apraxia of speech",
abstract = "Background and purpose: The non-fluent/agrammatic variant of primary progressive aphasia (agPPA) is a heterogeneous diagnosis wherein some individuals have apraxia of speech (AOS). When agPPA includes AOS, a tauopathy is the likely underlying pathology. Recently, [18F]AV-1451 was developed for the in-vivo assessment of tau. In this study, we compared patterns of tau tracer uptake in patients with agPPA with and without AOS. Methods: Nine patients with agPPA (four without AOS) underwent tau positron emission tomography imaging with [18F]AV-1451. Uptake of [18F]AV-1451 was assessed as cortical to cerebellar crus ratio (standard uptake value ratio) in cortical regions of interest measured using the MCALT atlas and compared voxel-wise in SPM12. Each patient was age- and sex-matched to three controls. Results: The agPPA without AOS showed uptake in the left frontal and temporal lobes, whereas agPPA with AOS showed uptake in the bilateral supplementary motor areas, frontal lobes, precuneus and precentral gyrus relative to controls. The left precentral gyrus had uptake in agPPA with AOS relative to those without AOS. Conclusions: This cross-sectional study suggests that [18F]AV-1451 uptake in the precentral gyrus is implicated in AOS in agPPA.",
keywords = "apraxia of speech, primary progressive aphasia, tau positron emission tomography, [18F]AV-1451",
author = "Rene Utianski and Whitwell, {Jennifer Lynn} and Christopher Schwarz and Duffy, {J. R.} and H. Botha and Heather Clark and Machulda, {Mary Margaret} and Senjem, {M. L.} and Knopman, {David S} and Petersen, {Ronald Carl} and Jack, {Clifford R Jr.} and Val Lowe and Josephs, {Keith Anthony}",
year = "2018",
month = "11",
day = "1",
doi = "10.1111/ene.13733",
language = "English (US)",
volume = "25",
pages = "1352--1357",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell",
number = "11",

}

TY - JOUR

T1 - Tau uptake in agrammatic primary progressive aphasia with and without apraxia of speech

AU - Utianski, Rene

AU - Whitwell, Jennifer Lynn

AU - Schwarz, Christopher

AU - Duffy, J. R.

AU - Botha, H.

AU - Clark, Heather

AU - Machulda, Mary Margaret

AU - Senjem, M. L.

AU - Knopman, David S

AU - Petersen, Ronald Carl

AU - Jack, Clifford R Jr.

AU - Lowe, Val

AU - Josephs, Keith Anthony

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background and purpose: The non-fluent/agrammatic variant of primary progressive aphasia (agPPA) is a heterogeneous diagnosis wherein some individuals have apraxia of speech (AOS). When agPPA includes AOS, a tauopathy is the likely underlying pathology. Recently, [18F]AV-1451 was developed for the in-vivo assessment of tau. In this study, we compared patterns of tau tracer uptake in patients with agPPA with and without AOS. Methods: Nine patients with agPPA (four without AOS) underwent tau positron emission tomography imaging with [18F]AV-1451. Uptake of [18F]AV-1451 was assessed as cortical to cerebellar crus ratio (standard uptake value ratio) in cortical regions of interest measured using the MCALT atlas and compared voxel-wise in SPM12. Each patient was age- and sex-matched to three controls. Results: The agPPA without AOS showed uptake in the left frontal and temporal lobes, whereas agPPA with AOS showed uptake in the bilateral supplementary motor areas, frontal lobes, precuneus and precentral gyrus relative to controls. The left precentral gyrus had uptake in agPPA with AOS relative to those without AOS. Conclusions: This cross-sectional study suggests that [18F]AV-1451 uptake in the precentral gyrus is implicated in AOS in agPPA.

AB - Background and purpose: The non-fluent/agrammatic variant of primary progressive aphasia (agPPA) is a heterogeneous diagnosis wherein some individuals have apraxia of speech (AOS). When agPPA includes AOS, a tauopathy is the likely underlying pathology. Recently, [18F]AV-1451 was developed for the in-vivo assessment of tau. In this study, we compared patterns of tau tracer uptake in patients with agPPA with and without AOS. Methods: Nine patients with agPPA (four without AOS) underwent tau positron emission tomography imaging with [18F]AV-1451. Uptake of [18F]AV-1451 was assessed as cortical to cerebellar crus ratio (standard uptake value ratio) in cortical regions of interest measured using the MCALT atlas and compared voxel-wise in SPM12. Each patient was age- and sex-matched to three controls. Results: The agPPA without AOS showed uptake in the left frontal and temporal lobes, whereas agPPA with AOS showed uptake in the bilateral supplementary motor areas, frontal lobes, precuneus and precentral gyrus relative to controls. The left precentral gyrus had uptake in agPPA with AOS relative to those without AOS. Conclusions: This cross-sectional study suggests that [18F]AV-1451 uptake in the precentral gyrus is implicated in AOS in agPPA.

KW - apraxia of speech

KW - primary progressive aphasia

KW - tau positron emission tomography

KW - [18F]AV-1451

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U2 - 10.1111/ene.13733

DO - 10.1111/ene.13733

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JO - European Journal of Neurology

JF - European Journal of Neurology

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