TY - JOUR
T1 - Targeting the adaptive immune system
T2 - New strategies in the treatment of atherosclerosis
AU - Zarzycka, Barbara
AU - Nicolaes, Gerry A.F.
AU - Lutgens, Esther
N1 - Publisher Copyright:
© Informa UK, Ltd.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Atherosclerosis is a lipid-driven chronic inflammatory disease of the arterial wall. Current treatment of atherosclerosis is focused on limiting its risk factors, such as hyperlipidemia or hypertension. However, treatments that target the inflammatory nature of atherosclerosis are still under development. Discovery of novel targets involved in the inflammation of the arterial wall creates opportunities to design new therapeutics that successfully modulate atherosclerosis. Here, we review drug targets that have proven to play pivotal roles in the adaptive immune system in atherosclerosis, and we discuss their potential as novel therapeutics.
AB - Atherosclerosis is a lipid-driven chronic inflammatory disease of the arterial wall. Current treatment of atherosclerosis is focused on limiting its risk factors, such as hyperlipidemia or hypertension. However, treatments that target the inflammatory nature of atherosclerosis are still under development. Discovery of novel targets involved in the inflammation of the arterial wall creates opportunities to design new therapeutics that successfully modulate atherosclerosis. Here, we review drug targets that have proven to play pivotal roles in the adaptive immune system in atherosclerosis, and we discuss their potential as novel therapeutics.
KW - adaptive immune system
KW - atherosclerosis
KW - drug discovery
KW - target identification
UR - http://www.scopus.com/inward/record.url?scp=84928616803&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928616803&partnerID=8YFLogxK
U2 - 10.1586/17512433.2015.1025052
DO - 10.1586/17512433.2015.1025052
M3 - Review article
C2 - 25843158
AN - SCOPUS:84928616803
SN - 1751-2433
VL - 8
SP - 297
EP - 313
JO - Expert review of clinical pharmacology
JF - Expert review of clinical pharmacology
IS - 3
ER -