Targeted treatment for chronic lymphocytic leukemia

Aisha Masood; Taimur Sher; Aneel Paulus; Kena C. Miller; Kasyapa S. Chitta; Asher Chanan-Khan

doi:10.2147/OTT.S7173

Targeted treatment for chronic lymphocytic leukemia

Aisha Masood, Taimur Sher, Aneel Paulus, Kena C. Miller, Kasyapa S. Chitta, Asher Chanan-Khan

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

The treatment of chronic lymphocytic leukemia (CLL) has evolved over the last few decades. Recognition has increased of several key components of CLL biology currently manipulated for therapeutics. A milestone in the treatment of CLL was reached with the incorporation of immunotherapy with conventional chemotherapy. The fludarabine/ cyclophosphamide/rituximab combination has demonstrated survival advantage for the first time in the treatment of CLL. Several other biological compounds are being explored with the hope of improving responses, impacting survival, and ultimately curing CLL. Important agents being tested are targeted on CLL surface molecules and their ligands, signal transduction protein and oncogenes. This review provides a brief summary of the recent advances made in preclinical and clinical investigation of selected promising therapeutic agents, which lead the target-directed therapeutic approach.

Original language	English (US)
Pages (from-to)	169-183
Number of pages	15
Journal	OncoTargets and Therapy
Volume	4
DOIs	https://doi.org/10.2147/OTT.S7173
State	Published - 2011

Keywords

Akt inhibitors
Bcl-2 inhibitors
CLL
Cyclin d kinase inhibitors
Heat shock protein inhibitors
Immunomodulatory drugs
Monoclonal antibodies

ASJC Scopus subject areas

Oncology
Pharmacology (medical)

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10.2147/OTT.S7173

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title = "Targeted treatment for chronic lymphocytic leukemia",

abstract = "The treatment of chronic lymphocytic leukemia (CLL) has evolved over the last few decades. Recognition has increased of several key components of CLL biology currently manipulated for therapeutics. A milestone in the treatment of CLL was reached with the incorporation of immunotherapy with conventional chemotherapy. The fludarabine/ cyclophosphamide/rituximab combination has demonstrated survival advantage for the first time in the treatment of CLL. Several other biological compounds are being explored with the hope of improving responses, impacting survival, and ultimately curing CLL. Important agents being tested are targeted on CLL surface molecules and their ligands, signal transduction protein and oncogenes. This review provides a brief summary of the recent advances made in preclinical and clinical investigation of selected promising therapeutic agents, which lead the target-directed therapeutic approach.",

keywords = "Akt inhibitors, Bcl-2 inhibitors, CLL, Cyclin d kinase inhibitors, Heat shock protein inhibitors, Immunomodulatory drugs, Monoclonal antibodies",

author = "Aisha Masood and Taimur Sher and Aneel Paulus and Miller, {Kena C.} and Chitta, {Kasyapa S.} and Asher Chanan-Khan",

year = "2011",

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language = "English (US)",

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pages = "169--183",

journal = "OncoTargets and Therapy",

issn = "1178-6930",

publisher = "Dove Medical Press Ltd.",

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T1 - Targeted treatment for chronic lymphocytic leukemia

AU - Masood, Aisha

AU - Sher, Taimur

AU - Paulus, Aneel

AU - Miller, Kena C.

AU - Chitta, Kasyapa S.

AU - Chanan-Khan, Asher

PY - 2011

Y1 - 2011

N2 - The treatment of chronic lymphocytic leukemia (CLL) has evolved over the last few decades. Recognition has increased of several key components of CLL biology currently manipulated for therapeutics. A milestone in the treatment of CLL was reached with the incorporation of immunotherapy with conventional chemotherapy. The fludarabine/ cyclophosphamide/rituximab combination has demonstrated survival advantage for the first time in the treatment of CLL. Several other biological compounds are being explored with the hope of improving responses, impacting survival, and ultimately curing CLL. Important agents being tested are targeted on CLL surface molecules and their ligands, signal transduction protein and oncogenes. This review provides a brief summary of the recent advances made in preclinical and clinical investigation of selected promising therapeutic agents, which lead the target-directed therapeutic approach.

AB - The treatment of chronic lymphocytic leukemia (CLL) has evolved over the last few decades. Recognition has increased of several key components of CLL biology currently manipulated for therapeutics. A milestone in the treatment of CLL was reached with the incorporation of immunotherapy with conventional chemotherapy. The fludarabine/ cyclophosphamide/rituximab combination has demonstrated survival advantage for the first time in the treatment of CLL. Several other biological compounds are being explored with the hope of improving responses, impacting survival, and ultimately curing CLL. Important agents being tested are targeted on CLL surface molecules and their ligands, signal transduction protein and oncogenes. This review provides a brief summary of the recent advances made in preclinical and clinical investigation of selected promising therapeutic agents, which lead the target-directed therapeutic approach.

KW - Akt inhibitors

KW - Bcl-2 inhibitors

KW - CLL

KW - Cyclin d kinase inhibitors

KW - Heat shock protein inhibitors

KW - Immunomodulatory drugs

KW - Monoclonal antibodies

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U2 - 10.2147/OTT.S7173

DO - 10.2147/OTT.S7173

M3 - Review article

C2 - 22162923

AN - SCOPUS:84858807412

SN - 1178-6930

VL - 4

SP - 169

EP - 183

JO - OncoTargets and Therapy

JF - OncoTargets and Therapy

ER -

Targeted treatment for chronic lymphocytic leukemia

Abstract

Keywords

ASJC Scopus subject areas

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