Tamoxifen in the management of pseudoangiomatous stromal Hyperplasia

Sandhya Pruthi, Carol Reynolds, Ruth E. Johnson, John J. Gisvold

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Pseudoangiomatous stromal hyperplasia (PASH) is a relatively uncommon histologic finding in breast specimens. The clinicopathologic spectrum of this disease entity can range from a focal nonsignificant microscopic finding to a dominant palpable breast mass. To confirm the diagnosis, a biopsy is required primarily to distinguish PASH from a low-grade angiosarcoma. The mammographic description of PASH is a round or ovoid, circumscribed or partially circumscribed mass. The sonographic feature is a hypoechoic mass. PASH is similar to a fibroadenoma in clinical and imaging features. Progressive breast enlargement associated with engorgement, cyclical breast pain, and burning sensation is of significant concern for some women. The management of the palpable mass and associated symptoms has included excisional biopsy, often leading to recurrent excisions and even mastectomy. This report documents an impressive response to tamoxifen in a patient with PASH presenting with breast enlargement, pain, and breast masses. To our knowledge, there are no reports on the use of tamoxifen or other selective estrogen receptor modulators in the management of this benign breast condition.

Original languageEnglish (US)
Pages (from-to)434-439
Number of pages6
JournalBreast Journal
Volume7
Issue number6
DOIs
StatePublished - Dec 1 2001

Keywords

  • Benign breast diseases
  • Low-grade angiosarcoma
  • Stromal hyperplasia
  • Tamoxifen

ASJC Scopus subject areas

  • Internal Medicine
  • Surgery
  • Oncology

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