T cell subset-specific susceptibility to aging

Marta Czesnikiewicz-Guzik, Won Woo Lee, Dapeng Cui, Yuko Hiruma, David L. Lamar, Zhi Zhang Yang, Joseph G. Ouslander, Cornelia M. Weyand, Jörg J. Goronzy

Research output: Contribution to journalArticlepeer-review

255 Scopus citations

Abstract

With increasing age, the competence of the immune system to fight infections and tumors declines. Age-dependent changes have been mostly described for human CD8 T cells, raising the question of whether the response patterns for CD4 T cells are different. Gene expression arrays of memory CD4 T cells yielded a similar age-induced fingerprint as has been described for CD8 T cells. In cross-sectional studies, the phenotypic changes were not qualitatively different for CD4 and CD8 T cells, but occurred much more frequently in CD8 T cells. Homeostatic stability partially explained this lesser age sensitivity of CD4 T cells. With aging, naïve and central memory CD8 T cells were lost at the expense of phenotypically distinct CD8 effector T cells, while effector CD4 T cells did not accumulate. However, phenotypic shifts on central memory T cells were also more pronounced in CD8 T cells. This distinct stability in cell surface marker expression can be reproduced in vitro. The data show that CD8 T cells are age sensitive by at least two partially independent mechanisms: fragile homeostatic control and gene expression instability in a large set of regulatory cell surface molecules.

Original languageEnglish (US)
Pages (from-to)107-118
Number of pages12
JournalClinical Immunology
Volume127
Issue number1
DOIs
StatePublished - Apr 2008

Keywords

  • Aging
  • CD4
  • CD8
  • CD85
  • Immunosenescence
  • Killer immunoglobulin-like receptors
  • T-cell homeostasis
  • T-cell subset

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'T cell subset-specific susceptibility to aging'. Together they form a unique fingerprint.

Cite this