Abstract
The 2008 WHO classification of mature T- and NK-cell neoplasms recognizes 18 distinct clinico-pathological entities and a number of subgroups or provisional disease categories. The most important changes compared to the 2001 edition include recognition of chronic lymphoproliferative disorders of NK cells and EBV-positive T-cell lymphoproliferative disorder of childhood entities; redefinition of subcutaneous panniculitis-like T-cell lymphoma (TCL) as a neoplasm of T cells expressing α/β T-cell receptor and recognition of primary cutaneous γ/δ TCL, and separation of anaplastic large cell lymphoma into ALK positive and negative subtypes. With the help of molecular tools, investigators have unveiled some of the molecular events in T-cell lymphomagenesis. These include delineation of similarities between physiological T-cell subsets and some TCL and a number of gene specific genetic alterations. Although the findings have a long way to go before a clinical translation can be achieved, they raise a number of new potential diagnostic and treatment targets.
Original language | English (US) |
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Pages (from-to) | 99-110 |
Number of pages | 12 |
Journal | Diagnostic Histopathology |
Volume | 16 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2010 |
Keywords
- lymphoma, T cell, angioimmunoblastic
- lymphoma, T cell, peripheral
- lymphoma, large cell, anaplastic
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology